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Trade Names: Ipamorelin
Chemical Names: Ipamorelin, NNC 26-016
Routes: Subcutaneous Injection

Ipamorelin is a growth hormone releasing peptide (GHRP) similar to GHRP2 and GHRP6 that was developed by Novo Nordisk. It is a pentapeptide composed of 5 amino acids that causes a significant release of growth hormone from the anterior pituitary gland, and has the dual action of also suppressing somatostatin, a peptide hormone that inhibits the release of growth hormone. The benefits of using Ipamorelin are increased fat loss, maintenance of lean muscle tissue, rejuvenation and strengthening of joints, connective tissue and bone mass, as well as other anti aging benefits associated with GH treatment such as improved skin tone and hair quality. It can also be used to increase low GH levels when natural GH secretion has been inhibited by long-term abuse of synthetic GH.

Ipamorelin is the first growth hormone releasing peptide to be developed that has the unique selective property of stimulating only the release of GH without also significantly increasing cortisol, or prolactin, even at doses more than 200 times higher than an average effective dose. It has no effect on testosterone, LH, or FSH levels and no post cycle therapy is needed after using it. It releases GH with a strength comparable to GHRP6, but without the associated side effects. This makes ipamorelin a wonderful candidate for research and probably the safest peptide to use. In a clinical study conducted on 48 adult men, even mega doses of 600mcg/kg were demonstrated to be safe and well tolerated.

The recommended effective dose is 1mcg/kg of bodyweight (100mcg for a man weighing 100kg). It elevates GH levels for about 3.5 hours after subcutaneous injection, and best results are obtained when using 3 or 4 doses per day. For those who wish to use it only once a day for anti-aging purposes, the best time to use it is right before bed, preferably with a GHRH. Ipamorelin has a synergistic effect when administered during a natural GH pulse and optimal times for use are at night right before bed, pre workout or immediately post workout, and first thing in the morning.

The saturation dose for most GHRPs (GHRP2, GHRP6, Hexarelin) is generally defined as 1mcg/kg, meaning that any dose over that will have much less of an effect the higher you go over it. Ipamorelin also has a diminishing effect over 1mcg/kg but where Ipamorelin is unique, unlike the other GHRPs, is that it can be taken in significantly higher doses resulting in a mega-release of GH up to the entire amount present in the pituitary gland.

For an even greater synergistic effect ipamorelin should be taken together with a GHRH (growth hormone releasing hormone) like CJC1295 w/o DAC. The synergy is due to ipamorelin’s suppression of somatostatin, and that it increases the amount of GH release per somatotrope (cells in the pituitary that release growth hormone), while the GHRH increases the number of somatotropes that will release GH. What this means is that if ipamorelin on it’s own causes 4 ‘units’ to be released, and the GHRH causes 3 to be released, the synergistic effect of using them together could result in 15 being released!

Ipamorelin is usually supplied in 2mg vials containing the freeze-dried peptide, which needs to be reconstituted with bacteriostatic water. Once the peptide is reconstituted, it should be used within 8 weeks and should be stored in the fridge between 2°C - 8 °C. If the ipamorelin does not dissolve minutes do not shake the solution as this can damage the peptide. Gently swirl the mixture or leave it a while longer and it should dissolve within a few minutes.