GW-501516

Anyone here used GW-501516 already? I can get my hand on some, but have no idea how to use it.

Here is some info from Wikipedia:

GW-501516 (also known as GW-501,516, GW1516 or GSK-516) is a PPARδ modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPARδ and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease.[3][4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms;[7] it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.[8][9][10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar.[11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans.[14]

Concerns were raised prior to the 2008 Beijing Olympics that GW-501516 could be used by athletes as a performance enhancing drug which was not currently controlled by regulations or detected by standard tests. One of the main researchers from the study on enhanced endurance consequently developed a urine test to detect the drug, and made it available to the International Olympic Committee.[15] The World Anti-Doping Agency has also begun work on a test for GW-501516 and other related PPARδ modulators,[16] and they have been added to the prohibited list from 2009 onwards.[17] The compound has yet to be named a controlled or prohibited substance by any nation's drug enforcement or regulation agency. To date, no athlete is known to have tested positive for the substance, though the increase in endurance, muscle fiber performance, fat loss and metabolism suggests GW-501516 has the potential for ergogenic use and abuse.

Sounds promising. You be the guinea pig, and keep the rest of us informed.

does sound awesome admin, what form does it come in?

ShaneV wrote: Sounds promising. You be the guinea pig, and keep the rest of us informed.

Welcome to the forum, but to be honest I'll rather see someone else use it before me. But on the other hand it seems to be beneficial to HDL cholesterol increases.

spartacus wrote: does sound awesome admin, what form does it come in?

Not too sure, but I'm waiting for the supplier to get back to me. On wikipedia they mention an oral dose of 5mg, but by the sound of my supplier it appears to come in a vial.

admin wrote:

ShaneV wrote: Sounds promising. You be the guinea pig, and keep the rest of us informed.

Welcome to the forum, but to be honest I'll rather see someone else use it before me. But on the other hand it seems to be beneficial to HDL cholesterol increases.

Thanks. I'll make an intro post just now.

Doctari:

AICAR en GW1516 is dieselfde ding. Eintlik is dit GW501516. Dit is 'n Peroxisoom-Proliferator-geaktiveerde Reseptor-delta analoog of kortweg 'n PPAR-delta. Dis 'n molekule wat tot 'n mate "uncoupling" doen deurdat dit vetsure uit adipose weefsel verbrand eerder as koolhidrate as bron van energie vanuit speir weefsel. Dit beskerm eintlik die pankreas teen oormatige insulien sekresie tydens oefening deur onder andere insulien sensitiwiteit op spierselle te verbeter. Dus mobiliseer dit die vry vetsure makliker en maak dan ook die beskikbare insulien molekules meer sensitief om eerder vetsure oor die spiersel membrane te vervoer as glukose.

En dit is waar die performance enhancement inkom. Vet verbranding lewer baie meer energie vir baie langer as wat koolhidraat verbranding doen. Endurance atlete se metabolismes is geneties aangepas om vet te verbrand by voorkeur bo koolhidrate. Die in vitro studies het gewys aanvanklik 'n verbetering van 44% in die vet verbranding kapasiteit.

Rondom toetsing vir die AICAR molekule? Anti-Doping weet reeds daarvan. Die Duitsers het die bestaan van die molekule alreeds in 2009 beskryf en reeds toe al die endurance enhancement uitgewys. Of hulle al 'n toets het ddaarvoor weet ek nie, want die flippin artikel is in Duits geskryf en ek kan Duits lees, maar kon nie die volle abstract afgetrek kry nie.

Maar, ouboet, hier's eerder iets meer interessants. Gaan doen 'n search vir Follistatin - dis 'n myostatin-antagonist waaraan die ouens tans werk. Dit word lokaal ingespuit, veroorsaak gene-expression vir spier hipertrofie, maar slegs vir skelet spier. En, hier's die nice deel... Anders as met AAS, veroorsaak Follistatin PERMANENTE spier hipertrofie. Hmmn, heel interessant...

i will try it out for the forum.

Ek kry hoendervleis as ek doctari se gedeelte lees! Sounds Promising Admin! I want to get my Hand on Those things. Ill be a test subject

The GW-501516 actually reminds me of Metformin and what most people think it is supposed to do. It does do it, but not to the extend we want it to and then it has it's downs as well.

But seariously this is my fav part: "Dit word lokaal ingespuit, veroorsaak gene-expression vir spier hipertrofie, maar slegs vir skelet spier. En, hier's die nice deel... Anders as met AAS, veroorsaak Follistatin PERMANENTE spier hipertrofie. Hmmn, heel interessant..."

and it only effects the skeletal muscle and not the hart and organs!

Follistatin is fucking expensive megusta and I know someone who has used it...Although there is almost no way of getting a correct dosage for it. Google, myostation inhibitors...

I've had access to Follistatin for almost 2 years now, but the price puts me off. And as Gorilla mentioned, no-one knows how to use it.

I just emailed my guy again and asked him what the current price for Follistatin is, hopefully it's more affordable.

The price is INSANE! To run the dose my supplier used its going to work out to about R**** per month, Admin can I post the price or is it also illegal?

Im keen to give this a bash too,im type 2 diabetic,sounds
like it could improve on my situation,Im :sick: and tired
of schnacking glucophage!

More than willing to give it a go Providing my supplier can secure it at a reasonable price it looks very promising.

i've been reading about it as well as s-4 and osta , do u think it can be a replacement for AAS or more of stacking it with them to prevent most of their side effects ?

Andarine (S-4) and Ostarine will never replace AAS. They are no-where near as effective when it comes to muscle gains.


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good day guys

tell me admin the follistatin the grocer said it comes in a 20iu vail which is 18mg is this correct ?

Roozer wrote: good day guys

tell me admin the follistatin the grocer said it comes in a 20iu vail which is 18mg is this correct ?

I don't know, because the ones I can get come in 1mg vials.

I'm sitting on some Myostatin HMP 250

Planning to start next week so will start a log-heard good things about it from a few others that have tried it, so hoping for results

There was another guy i was chatting to who was starting GW 501516-will ask him about results

My buddy is very satisfied with results of GW501516. Been on for 2 months, dosing at 10mg per day says dramatic fat loss and increase in endurance
Also seems to have positive effect on cholesterol

You have to run it with carbs though, which doesn't go with keto doet im running.
He also reports injury recovery of tendonitis in elbows

I he also taking AICAR with the GW501516?

Looking forward to reading your Myostatin HMP 250 cycle log, Yohimbe!

Admin I am seriously game to try this stuff out if u get some to sample

admin wrote: I he also taking AICAR with the GW501516?

I sent him a message-he didn't say anything before about it.
Will let you know

MK wrote: Looking forward to reading your Myostatin HMP 250 cycle log, Yohimbe!

x2