Blindly suggesting glps with someone with no structure will make them end up being a smaller, fatter version of themselves.
And as much as literature says it helps with preventing muscle loss, sadly real world application doesnt see this, as most people dose it way to high, which puts them in such a massive defecit, then when they lose weight and hunger creeps back up, they use more, suppressing hunger more.
The trick is to : set a calorie defecit of about 300kcal from diet and 450kcal from cardio per day and take the lowest amount possible to control hunger. With reta, for my clients have ranged from 0.1mg 3x a week to 0.3mg 2x a week as a start. I actually prefer semaglutide as its cheaper and pretty damn good at low dose to control hunger.
What we need to understand is for every 1 kg of loss, the body will increase hunger by 5% and decrease fullness by 3%.
So you will have an increased hunger response by 25% after 5kgs of loss, and 15% less fullness after the same meal you were eating when you were 5kgs heavier.
That is when you increase dosing by 20-30% for the week.. So your 0.3mg dosing will go to 0.4-0.5mg, and your 0.1mg may go to 0.2mg 3x a week etc.
Remember we are normal human beings,not the 200+ kg individuals in the studies.
your dose should be predicated on your starting Hb1ac levels, if you have an hb1ac of close to 6 or 7, you will need to be heavy on the dosing.
If your hb1ac is like 5.1% you will need to use less.
BLOOD WORK IS NEEDED.
you dont want to be relatively insulin sensitive with an hb1ac of 5.2 starting of 2mg per week as you will feel like shit with side effects, increased heart rate from the glucagon component, nauseous, and most likely very hypo a lot of the time as you cant eat and get blood glucose up and then you lose ability to train etc.
By doing it this wwy you will not go lower than the certain calorie threshold that reduce hormone production such as testosterone etc, aswell as affecting leptin levels which when lowered from low carb intake and lower body fat, causing more of a rebound when you come off.
These drugs and your body are more intricate and than you think.
Remember these drugs are forcing your pituitary to work harder the more you use, the pituitary gland, like the thyroid, can eventually burn out, so fucking with many pathways at high outputs due to massive drug abuse, to me, sounds like a potential cluster fuck of epic proportions. Google the role of the pituitary and what processes shut down if that would burn out.
I do remeber trying to assist with the psoriasis treatment for the original poster and got met with resistance and shut down hence why I didn't bother to respond till this post about reta came up.
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