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Sibutramine

Sibutramine

Trade name: Sibutramine
Chemical composition: Sibutramine Hydrochloride
Dosage: 20mg per tablet
Unit size: 50 tablets per unit
Manufacturer: Genitec Pharm

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Manufacturer's Description:

Sibutramine hydrochloride is a selective serotonin and noradrenalin re-uptake inhibitor used for the medical management of obesity. This pharmaceutical is intended to be an adjunct to a reduced calorie diet, which will help increase weight loss compared to that achieved with modifying food intake alone. Sibutramine hydrochloride is not advertised as a rapid acting drug, but instead one that fosters slow, safe, and steady losses in fat mass which are maintained long-term.

Sibutramine hydrochloride exerts a weight-loss effect through two distinct mechanisms. It has a marked ability to suppress appetite, stimulate metabolism as well as daily caloric expenditure. A 10 mg dose can increase basal metabolic rate by up to 30%, which can last for at least six hours.

The most common side effect with Sibutramine is an increase in blood pressure. Others include dry mouth, sleeplessness, irritability, back pain, stomach upset, and constipation, all of which tend to become reduced during prolonged usage. More serious side effects include excitement, restlessness, loss of consciousness, confusion, agitation, weakness, shivering, clumsiness, rapid heartbeat, large pupils, vomiting, difficulty breathing, chest pains, swelling of feet, ankles or legs, fainting, disorientation, depression, high fever, eye pain, tremor, or excessive sweating.

Sibutramine hydrochloride may also be used for the management of obesity (including weight loss and maintenance) and should be used in conjunction with a monitored and reduced-calorie diet. This drug has been used with patients who have additional ailments including controlled hypertension, diabetes, and high cholesterol. The recommended starting dosage is 10 mg once daily, which is to be adjusted upwards to 20 mg after 4 weeks if weight loss has not been sufficiently initiated. Higher doses are not recommended.