androgen receptor sensitivity

  • bigboyf
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24 Jun 2012 11:03 #110480 by bigboyf
androgen receptor sensitivity was created by bigboyf
hey guys just a quick question. Do androgen receptors regain there sensitivity and 'upgrade' again after not being on cycle for a long period of time? We all know we made the best gains on our first cycles with virgin receptors, do they ever return to this level of sensitivity after abstinence from steroid use? If so what is this period?

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  • Novice!
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26 Jun 2012 13:36 #110770 by Novice!
Replied by Novice! on topic androgen receptor sensitivity
I'd like to know this as well, and if there are any ways to increase sensitivity again?

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  • jackrabbit1
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26 Jun 2012 14:31 #110782 by jackrabbit1
Replied by jackrabbit1 on topic androgen receptor sensitivity
The number of receptors play a role. If you need more then more are created.
It has nothing to do with "downgrading".
The problem is Cortisol etc which negates the effect of AAS. Its a balancing act.

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  • Megusta
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26 Jun 2012 14:58 - 26 Jun 2012 14:59 #110792 by Megusta
Replied by Megusta on topic androgen receptor sensitivity
Basically, one must view the receptor sites as parking spaces.

Envision a slew of parking spaces that are all empty. Now we are going to call these parking spaces your receptor sites and we shall call steroids the cars. Now I want you to imagine one of those old 1950's style drive up hamburger stands where the girls come up in roller skates and take your order. Typically one would order a burger, fries and a coke--ah the food of the gods--the waitress would take the order, go bring the information to the cook, who would in-turn make the food and the waitress would then bring the food to you and you would then begin eating which is the whole reason you came to the hamburger stand in the first place.

I think everyone can easily understand that. Which means everyone can easily understand all they need to know about the receptor sites because they do the exact same thing. We will keep with this hamburger stand model and explain what happens when you inject steroids

Remember how I said steroids were like the cars and the parking spaces were like the receptor sites? Well it is basically that simple. When you inject testosterone or any one of it's anabolic or androgenic derivatives, you are sending a whole slew of "cars" into your system. Now these "cars" are on a mission--just like you would be if you were hungry and heading to a hamburger stand. They have orders to place with the cells, but before they can place them they must first find a parking space.

Now let's say you have never used steroids before. If this were the case, it would be very much like a hamburger stand that was having a grand opening....lots and lots of empty parking spaces waiting for cars to fill them up and place their orders. The steroids (cars) enter the system and come to a brand new hamburger stand called your cells. Now these cells have never previously been open to the boat-load of anabolics that are now present in the system because they previously only dealt with what your body naturally produced. However, there are lots of extra parking spaces that can be utilized and so the steroids park themselves into these spaces.

Once they are parked a "waitress" called CYCLICl AMP literally crosses the cellular membrane which is totally impenetrably to anything else and takes the order from the steroid. The order is quite simple: Build More Muscle!!

The "waitress" then crosses back through the cellular membrane and brings the order to the "cook" called the Nucleus who begins to fill it by ordering its helpers called Ribosomes to produce muscle protein.. Now different steroids will have slightly different orders in that some may have a bigger order for the cook to fill--such as testosterone. The thing you have to realize is that a lot of times, after the order is placed, the steroid does not necessarily leave the parking space and make it available to other steroids.....it will often sit in the parking space even though it is no longer sending orders to the "waitress" to bring to the "cook", and this is where the problem of "DOWN-REGULATION" comes in. You see even if you send in more and more fresh new "cars" to occupy the receptor spaces, if they are already taken up by old "dead cars" you are shit out of luck.....

This is why you do not continually grow by injecting bigger and bigger doses of steroids. THERE ARE A LIMITED NUMBER OF PARKING SPACES. Now it would not be so bad if all the parking spaces were taken by "cars" that were sending orders to the cook, because that is when you grow. The problem is when there are "cars" that are no longer sending orders and on top of that have dead batteries which is preventing them from exiting the receptors parking space.

This is what the whole point of this article is....TOWING AWAY ALL THE DEAD "CARS" FROM THE RECEPTOR SITES PARKING SPACES AS TO FREE THEM UP FOR NEW, FRESH, HUNGRY "CARS" TO OCCUPY THEM...This will result in new muscle mass!

O.K. Megusta, I am with you so far, but what the f*** can I do about it?

The answer is ...PLENTY!

First and foremost, is to plan sensible courses. This is why I am an advocate of short courses designed in such a fashion as to have all drugs out of the system by the end of the cycle and then allow for a 3-4 week off time in which you are totally clean. If you stay on these monster 4-6 month courses, you just wind up screwing yourself and requiring that much longer of an off period. The longer you are on, the more the body recognizes that there is "too much" in the system and will begin to take counter measures. And the longer you are on, the more "dead cars" you will have sitting in the receptor parking spaces which means NO MORE GROWING!

Now with this in mind, how can we help get the cars out of there?

Well WE actually cannot, but the body can and will. Basically as time goes by, the body will free up the parking spaces just like a tow truck would remove a dead car from a parking space. However, you are at the mercy of time in this situation which is why it is important to utilize short courses that will cause less disturbance in the system, less "dead cars" in the receptor spaces and therefore less time needed for the body to remove them and free up the spaces.

That being said, it should be noted that even short course will pile up "dead cars" after a while and you should give yourself an extended clean out of 2 months at least once a year.

But Megusta, isn't there anything I can do to help speed the process?

Once again the answer is yes!

You can help speed the process up dramatically by increasing your metabolic rate...Speeding up the metabolic rate is akin to hiring extra tow trucks to clear out all those "dead cars" that are occupying the receptor sites!

Have you ever know a person who was much, much fatter than you and yet ate half as much?

These poor bastards think they were given the genetic shaft and try every diet fad imaginable only to stay fat. Their problem no longer lies in their eating habits--which is ironic--; it lies in their metabolism, which basically was shut down due to the excess eating and lack of exercise that got them fat in the first place. Once you understand this, you can easily control your weight for the rest of your life. But what the f*** does this have to due with steroid receptor sites?

EVERYTHING!

The same thing I would prescribe someone whose metabolism has shut down due to obesity, is the same thing I would prescribe someone who's receptor sites are all clogged and is no longer making progress....INCREASE THE METABOLIC RATE!!

Below I will outline a few ways this can be achieved in the constraints of a 4 week Receptor Clearing Cycle follwing the completion of a Muscle Building Course using anabolics:

Diet: I suggest cutting back 300 calories below maintenance per day during a 4 week off time from your anabolic regime...I also suggest eating 6-8 small meals spread out from early morning to late at night. The higher the number of meals you eat, the more your body has to go to work and break down the food which causes the metabolic rate to increase.

Aerobics: Yet another tool in the battle to increase the metabolism, I would suggest low level aerobics 5 times per week 30 minutes per session.

Pharmacology: It is important that one does not have ANY anabolics that are active in the system during this time period.....make sure that you have had a good 4 weeks since your last shot of long acting compound before you embark on this 4 week receptor clearing cycle....otherwise you are wasting your fucking time! That being said, I would suggest the use of the following compounds to help accelerate the Receptor Clearing Process:

1. D.N.P.-- Understand that this is a fucking vicious poison and a component in T.N.T., and I do not suggest it's use at all, but to be fair I must admit that NOTHING can raise the metabolic rate like D.N.P. can. Because this is well known, there are many people that will want to try it...This being the case, D.N.P. should only be used in the following manner during this course: 3 days on, 4 days off at a dose of 4mg per kilogram of bodyweight taken before bed----have plenty of towels around and a fan to keep you cool!

2. Cytomel--T3 is another booster of metabolic rate which is why the fitness models live on this stuff...it keeps you engines running high and burns the fat right off....In this case, we are more concerned with the fact that it increases the metabolic rate. Suggested use is 75mcg -100mcg 5 days on 2 days off for the 4 week course. Be carefull, cause it will most probably burn muscle as well!!

* Don't use D.N.P.---which I think is the smarter approach as it is very dangerous.
* Basically you go on what i a call fat loss diet.
* Other fatburners That speed up your metabolism like HEAT, ECA stacks and clen buterol can also work to an extend.

There you have it...a brief simple suggestion on your receptors and how you might go about keeping them free and clear so you can continue to Grow, Grow, Grow and they begin to go to work.
Last edit: 26 Jun 2012 14:59 by Megusta.
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  • LXIX
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26 Jun 2012 15:48 #110800 by LXIX
Replied by LXIX on topic androgen receptor sensitivity
Nice one.
Thanks Megusta!

Time flies like an arrow
Fruit flies like a banana

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  • MRfeathers
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26 Jun 2012 15:51 #110802 by MRfeathers
Replied by MRfeathers on topic androgen receptor sensitivity
thanx megusta, where do you keep finding all this shit from ha ha

[IMG


keep calm and listen to Feathers

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26 Jun 2012 16:41 #110810 by Pyroclasm
Replied by Pyroclasm on topic androgen receptor sensitivity
"These poor bastards think they were given the genetic shaft" hahahahahahahahahaha! Funny guy! I love it when things get explained using metaphors. I understand it much better then. +1 bud!

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26 Jun 2012 16:45 #110811 by Megusta
Replied by Megusta on topic androgen receptor sensitivity

Pyroclasm wrote: "These poor bastards think they were given the genetic shaft" hahahahahahahahahaha! Funny guy! I love it when things get explained using metaphors. I understand it much better then. +1 bud!


hey where's that +1 ur talking bout? :whistle:

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26 Jun 2012 16:51 - 26 Jun 2012 16:52 #110813 by Megusta
Replied by Megusta on topic androgen receptor sensitivity

rvp01 wrote: thanx megusta, where do you keep finding all this shit from ha ha


It's part of my 5-year steroid research archive. Been researching anabolics for a few years to make sure i get the best 1st cycle that i can have and i'm still learning new things. I printed this document a few years back because i was asking the same question that this thread is about.
Last edit: 26 Jun 2012 16:52 by Megusta.

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26 Jun 2012 16:52 #110814 by Pyroclasm
Replied by Pyroclasm on topic androgen receptor sensitivity
Haha relax! I am waiting to reload then you will get yours. (no homo)

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  • jackrabbit1
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26 Jun 2012 17:31 #110816 by jackrabbit1
Replied by jackrabbit1 on topic androgen receptor sensitivity
So.... any comments on this then?

thinksteroids.com/articles/androgen-receptor-regulation/

I am indebted to one of my former colleagues at Dirty Dieting for contributing these first several arguments, which are from one of his published articles. I could never have thought of them myself:

“Users of anabolics certainly have elevated levels of androgens, but they have very few testosterone receptors in their muscles…The paradox for natural bodybuilders is that they have plenty of receptors but not enough testosterone.”

Response: there are no studies in the literature demonstrating any such thing. The above statement is an assertion only, and therefore cannot be accepted as evidence that AAS use in athletes downregulates the AR.

“Users of anabolics, on the other hand, have more androgens than they need, so their training should be oriented exclusively toward re- opening the testosterone receptors.”

This statement deals with the issue of sensitivity, not of regulation, but again the claim is unsupported. Users of anabolics find value in the increased doses of androgen, and advanced users may well need all that they are using simply to maintain their far-above-normal mass, let alone gain further mass. The reference to “re-opening” the testosterone receptors is dubious at best, since the receptors are not closed, nor is their any indication in any scientific literature that such could possibly be the case, or that some given style of training will remedy any such (nonexistent) condition.

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26 Jun 2012 18:00 #110820 by Megusta
Replied by Megusta on topic androgen receptor sensitivity
Interesting read Jack! nice! ;)

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  • Muscleaddict
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26 Jun 2012 19:13 - 26 Jun 2012 19:45 #110825 by Muscleaddict
Replied by Muscleaddict on topic androgen receptor sensitivity
Good read but Megusta rather don't post other peoples articles as your own and switch their names with yours. Give credit where credit is due with a link or reference if you are copy/pasting other guys research.
Last edit: 26 Jun 2012 19:45 by Muscleaddict.
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26 Jun 2012 21:32 #110846 by Pyroclasm
Replied by Pyroclasm on topic androgen receptor sensitivity
Just did your karma Megusta

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