LGD-4033 dosing confusion?

Admin im confused on the dosing of the lgd4033 capsules 10mg? The studies show 1mg per day being the highest dose administered. The result was lean muscle mass incease by 1.5kg in 3 weeks maybe less without weight training.Also side affects were Significant at this dose suppression of natural test and Hdl at 1mg per day.So why would someone go over 1mg per day? and why would the sarm supplements be doses at 10mg?

Link to studies? 1mg is on the very low end and probably for medical purposes. Most logs are run on 10mg and up and that would be the best starting point for athletes.

Witwolf wrote: Link to studies? 1mg is on the very low end and probably for medical purposes. Most logs are run on 10mg and up and that would be the best starting point for athletes.

please explain how 1mg is on the low side if subjects gained 1.5kg of lean body mass in 3 weeks without weight training. what logs?? info on forums?? with training and diet u could potentially double those figures. Where is there information that recommends athletes should use 10mg as a starting point.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/

*edit* I typed a long reply but its full of spelling mistakes (on my phone). Will reply tomorrow.

Endomorph wrote: Admin im confused on the dosing of the lgd4033 capsules 10mg?

Why are you asking me specifically? Do you think I came up with the 10mg dosage everyone on the planet is using?

Bodybuilders are much better at finding the optimal dosages, just look at every other drug used in the bodybuilding underground if you need proof. It's bodybuilders that came up with the best PCT protocols and not researchers for example.

Endomorph wrote: what logs?? info on forums??

Yes, logs on forums like this one, the one you are using now. If it's scientific evidence you are looking for you came to the wrong place.

I don't know what you expect us to answer you, because we are all experimenting with these drugs just like the researchers. They don't even know how to use it properly yet and neither do we, we are going on feedback of others and the current consensus among bodybuilders is that 10mg per day is the best for OUR purposes.

Why don't you take 1mg per day and let us know what you find as far as results go? Perhaps you find that it's adequate for bodybuilding use and we will all be very grateful for your contribution.

www.google.co.za/search?q=lgd+ideal+dosage&ie=&oe=

A simple google search reveals that generally all aas related sites recommend 10mgs.Remember, these dosages are for athletes, "gym rats" and bodybuilders. You are using a study with a "[...] primary aim [of assessing] the safety and tolerability of escalating doses of LGD-4033" to argue dosage for building mass, as that is the intended purpose of LP's LGD-4033.

The dosages were used to study the health effects. They mention that "the [...]primary aim was to establish safety and tolerability rather than efficacy."; efficacy being increase in LBM addressing muscle-wasting diseases, etc. They also explicitly state that "...the study duration was not designed to demonstrate maximal effects on skeletal muscle mass and muscle strength which were not the primary outcomes of the trial".


The study reveals that "LGD-4033 doses of 0.1, 0.3, and 1.0 mg were selected for multiple dosing over 21 days because a previous phase I single ascending-dose study had established the safety of up to 22 mg LGD-4033.". They do state that suppression and other negative effects were causal to dose, so even though 22mgs has been proven to be safe, I would guess suppression and cholesterol are affected more adversely at these dosages.

Furthermore, "[l]ean body mass increased dose dependently" which support the general consensus that for overall increase in mass, using resistance training on a caloric surplus diet, a dosage higher than 1mg yields better results.


Either way, like admin said, if you are looking for scientific evidence to back the countless logs and forum posts available on the internet, you won't find that here. However, if you are willing to compare this study to the information available on the net, you will see the trend.

Use 200mg test (trt dose) for 12 weeks, then use 400mg test for 12 weeks and compare the results. Higher doses yield better results until the point of diminishing returns are reached, where side effects exceed benefits. Luckily the weight-lifting community has already tested the waters for us, giving an indication as to what sort of dosage and duration work well with LGD. This is how I understand, LP would have decided on their LGD4033 dose.

Maybe 1mg p.d would be sufficient for your goals. For the general weight-lifting community it probably isn't. Thus most people run 500mg of Test per week instead of 200mg, which also helps in building mass, albeit not as significant.

Upon discontinuation of LGD-4033, the hormone levels returned to baseline by day 56.

That was copied from the study with no Post Cycle Therapy they also state lipids returned to baseline and that liver enzymes were not elevated.

Sounds good to go.

admin wrote:

Endomorph wrote: Admin im confused on the dosing of the lgd4033 capsules 10mg?

Why are you asking me specifically? Do you think I came up with the 10mg dosage everyone on the planet is using?

Bodybuilders are much better at finding the optimal dosages, just look at every other drug used in the bodybuilding underground if you need proof. It's bodybuilders that came up with the best PCT protocols and not researchers for example.

Because alot of general info on sarms has come from u thought u would be the right member to shed some light on this....want ask for info directly again i do apologise

Yes and Most bodybuilders abuse most drugs. This is why Im questioning the dose at 10mg is necessary if studies show gains of 1.5kg in 3 weeks without weight training and significant side effects on natural test and hdl levels.

Cant try 1mg if supplements are dosed at 1Omg. i would prefer a 1mg starting point.

Rooibull is right test levels did bounce back and hdl at 1mg.

Rooi Bul 86 wrote: Upon discontinuation of LGD-4033, the hormone levels returned to baseline by day 56.

That was copied from the study with no Post Cycle Therapy they also state lipids returned to baseline and that liver enzymes were not elevated.

Sounds good to go.

10mg it will have to be.

would u run test with this? if the Lgd at 10mg will shut u down if 1mg suppresses natuarl test .

admin wrote:

Endomorph wrote: what logs?? info on forums??

Yes, logs on forums like this one, the one you are using now. If it's scientific evidence you are looking for you came to the wrong place.

I don't know what you expect us to answer you, because we are all experimenting with these drugs just like the researchers. They don't even know how to use it properly yet and neither do we, we are going on feedback of others and the current consensus among bodybuilders is that 10mg per day is the best for OUR purposes.

Why don't you take 1mg per day and let us know what you find as far as results go? Perhaps you find that it's adequate for bodybuilding use and we will all be very grateful for your contribution.

i would if i could dose at 1mg guess will have to start at 10mg.

Thanks Gents.

Not trying to be funny or anything but where the hang did you manage to find lgd in S.A!?(not asking for sources just a rhetorical question).I was under the impression that the only reputable company to supply sarms here was lp and they don't have lgd on there product list do they?

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LP did add LGD to their product range about a month ago

Endomorph, just to branch off what was said above.

Drugs don't always give linear results based on liners doses. You can't extrapolate the results of 1mg to 10mg, and expect ten times the gains. Imagine if you plot a graph, Y-axis is gains, X-axis is drug dose. As X increases, so will Y, but not a constant relationship. It'll more likely look like Sine curve rather than a straight line.

Hope it makes sense mate.

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good topic

Shot rooi bul I didn't know that,I will definitely look into it..

Lol and and even sometimes it will resemble a cot graph depending on how your body reacts to hormones :rolleyes:

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Geez I hope not...

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Furk wrote: Endomorph, just to branch off what was said above.

Drugs don't always give linear results based on liners doses. You can't extrapolate the results of 1mg to 10mg, and expect ten times the gains. Imagine if you plot a graph, Y-axis is gains, X-axis is drug dose. As X increases, so will Y, but not a constant relationship. It'll more likely look like Sine curve rather than a straight line.

Hope it makes sense mate.

I understand the theory.

Thanks

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