Crusing & Blasting - any receptor down regulation?

Hey all,

So I have been wondering about cruising and blasting and running a higher than TRT dose for an extended period of time and whether this may cause any sort of receptor down regulation / desensitization?

I am specifically referring to only testosterone being used. Does this occur or not really?
If it does, what happens with people who are on actual TRT doses or is the dose low enough for no down regulation to occur?

I understand that running a higher dose for an extended period of time can put strain on ones body, cholestrol levels, blood pressure which can in turn affect the kidneys and obviously strain on ones natural production of test and is therefore not recommended.
Although that isn't really what this thread is about

Much debate on this one bud but the way I see it is receptor cells just like all cells in our body are continously dying off and being replaced so it should be a temporary issue. I have been b&c for a while and still seem to respond so it appears no down regulation.

Perhaps someone else can throw some info on the subject.

You are correct Fillet.

I remeber you also asked about it quite some time back. I also see it like you see it.

FIllet wrote: Much debate on this one bud but the way I see it is receptor cells just like all cells in our body are continously dying off and being replaced so it should be a temporary issue. I have been b&c for a while and still seem to respond so it appears no down regulation.

Perhaps someone else can throw some info on the subject.

My vote for damn sure your receptors down-regulate!

I actually had to take my wife to doc yesterday, asked her opinion as the same should happen to men on hrt/trt. Her opinion is they down regulate briefly as cells continually get replaced. She also said dosage related so high dose for prolonged periods then yes but not on low dose such as trt. Hence a blast and cruise should be fine as long as you dont blast very long. Then i got the normal as expected that its not good for you and hcg will give you cancer. But so will all the stuyvesant i smoke. many opinions and hard to have a factual answer. Facts are continously blasting you down regulate. Taking steriods will shave a few years off your life but this we know.

Alright, thanks for the info guys.

So prolonged use of higher doses certainly leads to down regulation of the receptors.
Do we know how long it takes the receptors to regenerate - what sort of "off time" or cruise time one would should consider in order for the receptors to regenerate?

I assume blasts should be 12 - 16 weeks at most?


@Fillet, if I may ask what test doses do you cruise on and do you blast on?

I cruise on 250 and blast on 1500. But i weigh a ton. What are your stats?

FIllet wrote: I cruise on 250 and blast on 1500. But i weigh a ton. What are your stats?

I cruise on 200mg per cycle of halflife, blast i dont much increase, 400mg mabey, but i add compounds when blasting.

But your body still responds Oups???

Interesting, thanks for the inf o guys!

Fillet, 1500 sounds insane! I've been pretty happy with my 500 on a cycle, towards the end I really start to notice the extra weight and water and such.

PsyCLown wrote: Interesting, thanks for the inf o guys!

Fillet, 1500 sounds insane! I've been pretty happy with my 500 on a cycle, towards the end I really start to notice the extra weight and water and such.

Fillet is at 150Kg+- that’s normal for guys his weight

FIllet wrote: But your body still responds Oups???

Yes, focused training and diet and the gains are good. Currently my cruze is on 200mg Equi & 200mg test, got an annoying old rugby injury but its healing nicely with the equi

I advise those on TRT to leave the huge blast of Testosterone and rather focus the cycle on other compounds. Your receptors are fried after a big blast.

Oupa wrote:

FIllet wrote: I cruise on 250 and blast on 1500. But i weigh a ton. What are your stats?

I cruise on 200mg per cycle of halflife, blast i dont much increase, 400mg mabey, but i add compounds when blasting.

I'm sure this will help plenty of us. +1 Old man

Pyroclasm wrote: I advise those on TRT to leave the huge blast of Testosterone and rather focus the cycle on other compounds. Your receptors are fried after a big blast.

Hmm, so rather increase the test dose a bit and throw in some other oils?
Deca, tren, equi or whatever?

Cruising and blasting on just test, the blast won't be as effective for those who run cycles and come off the exogenous test?

Yeah. Normally EQ with Deca or Tren, and 500mg Supertest, with some beautiful orals start and end.

Different strokes for different folks.
Test alone can do wanders. Pending diet and training.

Could be wrong but what iv noticed with myself the longer ones been at the training the less gear one needs to maintain a decent physic, might not have the same mass but with the low dose test and a bit of primo I'm happy won't be running high doses for a long time to come, switched to pharm grade test phizer at 150mg its more than enough, leaning towards only using pharm grade in future qualities something else compared to ugl.