SGLT2 Inhibitors

Hi Everyone. Just thought I'd share a little info about SGLT2 inhibitors since they're becoming increasingly popular in endocrinology. They aren't available in Public Health at the moment, however, they are available in private.

Their mechanism of action is in the name. They essentially block re-absorption of glucose in the kidneys.

Side Effects are not that common. However, due to the increase in glucose in the urine there is a higher risk of Urinary Tract Infections.

The obvious benefit one may see when usin this drug is weight loss and tight glucose control. In fact, it is commonly prescribed in Private for the purpose of weightloss. However, there are many other benefits. This drug out performs the standard Biguanides (Metformin) when looking at markers of cardiovascular health. This is what makes it so attractive to doctors.
"Dapagliflozin [An SGLT2 Inhibitor] reduced the rate of cardiovascular (CV) death or hospitalization for heart failure (HHF), did not adversely affect major adverse CV events (MACE) and possibly reduced progression of renal disease relative to placebo in patients with established atherosclerotic CV disease (CVD) or multiple risk factors for CVD"

This is a bit random but I was wondering if anyone on this forum is one this Hypoglycaemic agent and would recommend discussing using this (if you have the appropriate risk factors) with you GP.

My wife used forxiga but as you pointed out in a woman UTIs is very common for some. She is now on byetta and a slight rash at the injection site has been the only problem, glucophage at 2000mg on its own was not enough to bring insulin under 5.

00pump wrote: My wife used forxiga but as you pointed out in a woman UTIs is very common for some. She is now on byetta and a slight rash at the injection site has been the only problem, glucophage at 2000mg on its own was not enough to bring insulin under 5.

Did she notice any changes personally and in her health onn Forxiga?
Byetta or GLP-1 are also the only hypoglycaemic agents shown to be beneficial for cardiovascular risk however I have never seen them being used due to the fact that it is not available in public at the moment.

Her health is really good bar genetic elevated cholesterol and her insulin at 7 which the Dr wants under 5. Her blood pressure as most woman is very low at just over 100 over 70+/-. So her kidneys have never taken a wack and no strain on her heart so she probably isn't the best bet to see any positive benefit on health. I have seen glucophage being used off label for anti aging purposes now too, very small data but its there.