New products. GHRPs AND GHRHs

Some new products that I have heard about. I hear this stuff works like a dream a is not too costly. So I did some digging and this is what I found. I hear that it will become available in South Africa soon.

GHRPs AND GHRHs,including GHRP-6,Modified GRF.

*Dosing GHRPs*

The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin
& Hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you
add another 100mcg to that dose only 50% of that portion will be effective.
If you add an additional 100mcg to that dose only about 25% will be
effective. Perhaps a final 100mcg might add a little something to GH release
but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg
and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even
more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin
side-effects.

Ipamorelin is about as efficacious as GHRP-6 in causing GH release but even
at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg does not really increase prolactin &
cortisol but may do so slightly at higher doses. This rise is still within
the normal range.

GHRP-2 is a little more efficacious then GHRP-6 at causing GH release but at
the saturation dose or higher may produce a slight to moderate increase in
prolactin & cortisol. This rise is still within the normal range although
doses of 200 - 400mcg might make it the high end of the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing an increase
in GH release. However it has the highest potential to also increase
cortisol & prolactin. This rise will occur even at the 100mcg saturation
dose. This rise will reach the higher levels of what is defined as normal.

* Desensitization*.

GHRP-6 can be used at saturation dose (100mcg) three or four times a day
without risk of desensitization*.*

GHRP-2 probably at saturation dose several times a day will not result in
desensitization.

Hexarelin has been shown to bring about desensitization but in a long-term
study the pituitary recovered its sensitivity so that there was not
long-term loss of sensitivity at saturation dose. However dosing Hexarelin
even at 100mcg three times a day will likely lead to some down regulation
within 14 days.

If desensitization were to ever occur for any of these GHRPs simply
stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed several times a day every day will not
cause pituitary problems, nor significant prolactin or cortisol problems,
nor desensitize.

*GHRH *

Now Sermorelin, GHRH (1-44) and GRF(1-29) all are basically GHRH and have a
short half-life in plasma because of quick cleavage between the 2nd & 3rd
amino acid. This is no worry naturally because this hormone is secreted from
the hypothalamus and travels a short distance to the underlying anterior
pituitary and is not really subject to enzymatic cleavage. The release from
the hypothalamus and binding to somatotrophs (pituitary cells) happens
quickly.

However when injected into the body it must circulate before finding its way
to the pituitary and so within 3 minutes it is already being degraded.

That is why GHRH in the above forms must be dosed high to get an effect.

*GHRH analogs *

All GHRH analogs swap Alanine at the 2nd position for D-Aanine which makes
the peptide resistant to quick cleavage at that position. This means analogs
will be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the
DAC has other amino acid modifications. They are a glutamine (Gln or Q) at
the 8-position, alanine (Ala or A) at the 15-position, and a leucine (Leu or
L) at the 27-position.

The alanine at the 8th position enhances bioavailability but the other two
amino substitutions are made to enhance the manufacturing process (i.e.
create manufacturing stability).

For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or
tetra (4) substituted GRF(1-29) is a very effective peptide with a half-life
probably 30+ minutes.

That is long enough to be completely effective.

The saturation dose is also defined as 100mcg.

*Problem w/ Using any GHRH alone *

The problem with using a GHRH even the stronger analogs is that they are
only highly effective when somatostatin is low (the GH inhibiting hormone).
So if you unluckily administer in a trough (or when a GH pulse is not
naturally occurring) you will add very little GH release. If however you
luckily administer during a rising wave or GH pulse (somatostatin will not
be active at this point) you will add to GH release.

*Solution is GHRP + GHRH analog *

The solution is simple and highly effective. You administer a GHRH analog
with a GHRP. The GHRP creates a pulse of GH. It does this through several
mechanisms. One mechanism is the reduction of somatostatin release from the
hypothalamus, another is a reduction of somatostatin influence at the
pituitary, still another is increased release of GHRH from the brain and
finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but
use a different mechanism to increase cAMP formation which will further
cause GH release from somatotroph stores.

GHRH also has a way of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH is not additive it is synergistic. By that I mean:

If GHRH by itself will cause a GH release valued at 2
and GHRP itself will cause a GH release valued at 5

Together the GH is not 7 (5+2) it turns out to say 16!

*A solid protocol *

A solid protocol would be to use a GHRP + a GHRH analog pre-bed (to support
the nightime pulse) and once or twice throughout the day.

For anti-aging, deep restful restorative sleep, the once at night dosing is
all you need. For an adult aged 40+ it is enough to restore GH to youthful
levels.

However for bodybuilding or fatloss or injury repair multiple dosings can be
effective.

The GHRH analog can be used at 100mcg and as high as you want without
problems.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg
will probably be fine as well.

Again desensitization is something to keep an eye on particularly with the
highest doses of GHRP-2 and all doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together
will be effective.

This may be dosed several times a day to be highly effective.

A solid approach is a bit more conservative at 100mcg of GHRP-6 + 100mcg of
a GHRH analog dosed either once, twice, three or four times a day.

When dosing multiple times a day at least 3 hours should separate the
administrations.

The difference is once a day dosing pre-bed will give a youthful restorative
amount of GH while multiple dosing and or higher levels will give higher GH
& IGF-1 levels when coupled with diet & exercise will lead to muscle gain &
fatloss.

*Dose w/o food *

Administration should ideally be done on either an empty stomach or with
only protein in the stomach. Fats & carbs blunt GH release. So administer
the peptides and wait about 20 minutes (no more then 30 but no less then 15
minutes) to eat. AT that point the GH pulse has about hit the peak and you
can eat what you want.

Hope it is helpful.