Medication interactions

I'm new to this forum, so please forgive me if elements of my question has been asked before.

I'm on the following meds:

• bupropion
• methylphenidate
• fluticasone
• salbutamol
• montelukast

I would like to add the following to my regime:

1. Tamoxifen
2. Methenolone
3. Clomiphene
4. Mesterolone

(The latter list will, of course, be added in the correct order).

I would like to know if there are any major interactions between the meds from the first list and the meds from the second list. I've seen mentions of bupropion being problematic. I have, however, not seen what these adverse effects actually entail. I've also read that fluticasone used in conjunction with meds on second list could cause edema.

If anyone knows of any major interactions, please let me know, or be so kind as to direct me to the relevant resources.

If you're feeling particularly generous, recommendations for substitutes in the second list would be marvellous.

Thanks

It's impossible to tell the interaction because just the list you on a Dr can't tell you its interactions as no trials are done on such a combo.

I'll try answer some of your questions however I need to understand why you mention those drugs you want to use? What made you get the idea of primo and proviron ? Why are you not just looking at testosterone?

How old are you?

The wellbutrin won't be an issue, but a drop in anderogens post cycle will affect your sense of well-being.

You on alot of stimulating medication. What are the doses ? Tell me something, do you have results of your QT intervals, that isn't something you should neglect when on the meds you are on and the strain an asthma attack can have on you.

What's your resting heart rate and blood pressure? That needs to be in check before you look at a cycle as it will push whatever those numbers are up.. Just make sure you have your priorities straight when thinking about using gear when you have a number of underlying health conditions.

Thank you for all the salient points raised. I'm very much inexperienced so I'm just starting to comprehend all the intricacies.

To answer your questions:

I'm 37 years old, 78kg (down from 93kg in Feb 2020). 1.84m, BF just under 16%. Resting heart rate of 66.

Methylphenidate 54mg
Bupropion 300mg

I don't know what my QT intervals or blood pressure are. My asthma is well-controlled and has never given me issues when exercising.

I will take your advice and do a full check-up before embarking on this journey. Maybe even doing bloods to check cholesterol and the like.

With regards to the choice of gear; this is not a decision I take lightly and in an attempt to approach this with caution, I thought it wisest to start small and gauge my body's reaction before going all-in. This is by no means a final decision, as I still have a tonne of research to do.

Thank you once again for prodding and probing; it's already been of great benefit.

Based on that, I would recommend using testosterone which the body knows the best, those drugs you talkng about have different use cases. Always start with testosterone.

Your heart rate isn't bad, it isn't good either.. No Dr should perscribe stimulant medication without QT records.

You can go the whole big bang and test everything, I'm not sure if it's necessary, that depends upon what your goals are for doing the blood tests. You will always find something wrong if you look hard enough.. The big one is the blood pressure, as those two drugs are centrally acting which affect blood pressure in a significantly different way and has nothing to do with cholesterol, forget dopamine for a second, you targeting norepinephrine which is a stimulant so its always good to know what the adrenals are doing as well as the heart. High levels of sympathetic nerve activity is what they tie to people with hyperactivity, that alone increases blood pressure in "healthy people and why they able to help control blood pressure by renal sympathetic denervation, so blood pressure by these means sometimes goes unnoticed because you "healthy"... What you want to test after that is up to you..

Sisyphus wrote: I'm new to this forum, so please forgive me if elements of my question has been asked before.

I'm on the following meds:

• bupropion
• methylphenidate
• fluticasone
• salbutamol
• montelukast

I would like to add the following to my regime:

1. Tamoxifen
2. Methenolone
3. Clomiphene
4. Mesterolone

(The latter list will, of course, be added in the correct order).

I would like to know if there are any major interactions between the meds from the first list and the meds from the second list. I've seen mentions of bupropion being problematic. I have, however, not seen what these adverse effects actually entail. I've also read that fluticasone used in conjunction with meds on second list could cause edema.

If anyone knows of any major interactions, please let me know, or be so kind as to direct me to the relevant resources.

If you're feeling particularly generous, recommendations for substitutes in the second list would be marvellous.

Thanks

my questions in this, why are you wanting to only take a proviron and primo cycle?

have you had bloods done to see where your test levels are because if those are tanked, you would feel like you are suffering from depression as your test to estrogen ratio would be out.

get you free test, total test, SHBG and e2 checked in a blood test and that might explain the need for wellbutrin if you are suffering with some form of depression..

at 37, you maybe inline for TRT, and an oral cycle of primo and proviron isn't going to be a great idea.

Thank you Empire and OOpump.

I've been on the Bupropion since 2006 and the Methylphenidate since 2020. The last time I spoke with my psychiatrist he mentioned wanting to take me off the Bupropion, so at least that is something worth pursuing.

So my motivation for the oral-only cycle is multifold: convenience, fewer side effects, and to be frank, much less intimidating. I currently have a (platonic)friend staying with me and she would wholeheartedly and vocally disapprove of the taking of any gear. It would seem as if it would be easier to hide if it were only oral. The cycle is also not going to have very obvious gains, so in my opinion, it would be easier to explain away any noticeable improvements with harder work-outs and a cleaner diet.

As to the impetus of taking gear in the first place: I lost my partner of 11 years to suicide in 2020 and working out has given me a multitude of tangible goals (short, medium, to long-term), which has helped a lot in working through my issues. Moreover, I am not very keen to stay single forever and any aesthetic improvement will greatly boost my self-confidence in that regard.

My apologies for the emotional deep-dive no one asked for. I hope this paints a clearer picture of my incentives.

I will most certainly have my free test, total test, SHBG and e2 checked, as well as my liver and kidney functions. I am a little concerned about the possible hepatotoxicity of this stack so would like to have my bases covered.

Sisyphus wrote:
I'm 37 years old, 78kg (down from 93kg in Feb 2020). 1.84m, BF just under 16%. Resting heart rate of 66.

Based on these stats, no need for gear.
Plenty of natty gains still to be made.
Get on a good program, look after your health, eat good food, throw in some creatine and you're good.

get the blood done first to see where your natural test levels are, you may be able to get on to trt from your doc if they are progressive enough, and that way your plutonic friend will not know the difference.

trust me, I went through 2 divorces in a short space of time, I was using Wellbutrin and anti-anxiety meds, etc to combat it, and then saw my Test levels were shot, after 3 months of trt, I came off of those meds, and I am no longer using those anti-depressants and anti-anxiety meds.

The steroids will end up tanking those levels even more, so you will find that you have issues with mood even more.