Peptide. Here's a link to a thesis on the stuff:
CLICK
...and my breakdown of what the thesis say's GW501516 does:
The whole thing is about how GW501516 affects the metabolism of fatty acids. How it activates receptors responsible for regulating the expression of various genes involved in the metabolism of carbs, cholesterol and lipids as well as formation of new fat cells.
In the thesis they look at GW's effect on acetyl-CoA. If you eat more than you burn then your body produces too much acetyl-CoA and this is stored as fat. GW drastically reduces the enzyme ACC that's responsible for resulting in acetyl-CoA being stored as fat.
The data also shows that GW501516 upregulates CPT transcription. WTF is that? :blink: This facilitates the transport of fatty acids into mitachondria. These are the cells that turn fatty acids into usable energy where otherwise they could have been stored as fat.
Next it shows that GW501516 drastically reduces LPL gene activation. WTF? :blink: Lipoprotein Lipase is also involved in dreaded fat storage. Something about regulating much fatty acids are stored in adipose tissue. So reducing LPL means reducing fat storage.
The thesis also says how PPAR agonists like GW501516 (and they mention another I never heard of -GW610742) help regulate the 'reverse cholesterol transport process'. This is where our good HDL cholesterol moves bad LDL cholesterol from tissues in the body back to the liver where excess cholesterol is eliminated. Very good.
Also worth a mention is that GW501516 has been linked to possibly being carcinogenic in a study on mice. The doses use on the animals equate to about 10x the normal dose that we would take, and there is no evidence either way to prove that there is/isn't a risk. But as far as I know it has not been linked to cancer in humans.
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