Hi Guys
It has been a while since I have posted on this forum yet I am still a regular reader and find this forum to be the premier source of quality, real world information. Keep up the good work guys! This morning I came across Synarel (nafarelin acetate nasal solution) but can't find any info regarding its use for the bodybuilder. Is there anyone out there familiar with this chemical who could enlighten me?
It appears that this nasal spray when "given as a single dose, stimulates release of the pituitary gonadotrophins, luteinizing hormone (LH) and follicle stimulating hormone (FSH)" Regular use of the spray appears to have the opposite effect so perhaps it may not be of use during PCT, but what if one was to have a dose every 4 weeks or so while on course? I would assume that may assist in preventing your natural test production from shutting down?
Here is some info as printed on the package insert:
SYNAREL (Nasal Spray)
SCHEDULING STATUS:
S4
PROPRIETARY NAME
(and dosage form):
SYNAREL (Nasal Spray)
COMPOSITION:
Each bottle contains 60 doses of nafarelin acetate nasal solution (2 mg/mL as nafarelin base), and is supplied with a metered spray pump. Each spray delivers 200 micrograms of nafarelin base. SYNAREL contains benzalkonium chloride 0,1% (m/v) as preservative.
PHARMACOLOGICAL CLASSIFICATION:
A 21.12 Hormone inhibitors.
PHARMACOLOGICAL ACTION:
Nafarelin is an agonistic analogue of gonadotrophin releasing hormone (GnRH). Given as a single dose, nafarelin stimulates release of the pituitary gonadotrophins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), with consequent increase of ovarian and testicular steroidogenesis. During repeated twice daily dosing this response to stimulation gradually diminishes. Within about four weeks, daily administration leads to decreased pituitary gonadotrophin secretion and/or the secretion of gonadotrophins with lowered biological activity. There is a consequent suppression of gonadal steroidogenesis and inhibition of functions in tissues that depend on gonadal steroids for their maintenance.
Nafarelin is rapidly absorbed into the circulation after intranasal administration. Maximum plasma concentration is achieved ten to forty minutes after dosing and the plasma half-life is approximately three hours. Bioavailability of the intranasal dose averages 2,5% (range 1,2 to 5,6%).
INDICATIONS:
SYNAREL is indicated for the hormonal management of endometriosis, including pain relief and reduction of endometric lesions for a period of six months in patients 18 years and older.
SYNAREL is also indicated for use in controlled ovarian stimulation programmes prior to in vitro fertilisation, under the supervision of an infertility specialist.
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