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Ostarine (Acetamidoxolutamide) is an investigational selective androgen receptor modulator (SARM) developed by GTx Inc for treatment of conditions such as muscle wasting and osteoporosis.[1] Treatment with exogenous testosterone is effective in counteracting these symptoms but is associated with a range of side effects, the most serious of which is enlargement of the prostate gland, which can lead to benign prostatic hypertrophy and even prostate cancer. This means there is a clinical need for selective androgen receptor modulators, which produce anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in the prostate.[2] Ostarine was one of the first SARMs to be developed,[3] using the non-steroidal androgen antagonist bicalutamide as a lead compound.[4]
Ostarine is an orally active, potent and selective agonist for androgen receptors which was shown in animal studies to have anabolic effects in both muscle and bone tissue, but with no measurable effect on lutenizing hormone or follicle-stimulating hormone levels at the dose range tested, although it did increase prostate weight, with an androgenic potency around 1/3rd of its anabolic potency. It was shown in vitro to increase the ratio of osteoblast formation from bone marrow osteoprogenitor cells, and reduced the number of new osteoclasts formed. It produced dose-dependent increases in bone mineral density and mechanical strength in vivo, as well as decreasing body fat and increasing lean body mass.[5] However while human trials have shown evidence of similar efficacy, ostarine has a short half-life in humans of only 4 hours,[6] and while ostarine has gone through human trials up to Phase II with positive results,[7] longer acting analogues are currently in development which may be more suitable for clinical use.
Selective androgen receptor modulators may also be used by athletes to assist in training and increase physical stamina and fitness, potentially producing effects similar to anabolic steroids but with significantly less side effects. For this reason, SARMs have already been banned by the World Anti-Doping Agency since January 2008 despite no drugs from this class yet being in clinical use, and blood tests for all known SARMs are currently being developed.
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Admin,
Are you stacking something with the MGE and how long do you suggest that a person should use it for?
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Why MGE?
Split work load (One bringing in raw, one doing the capping)? Other reasons? Why not just release it under a known name?
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Inja wrote:
Why MGE?
Split work load (One bringing in raw, one doing the capping)? Other reasons? Why not just release it under a known name?
If SARM's are legal, for personal consumption. (Not sure, about this, please inform me if I'm wrong)
It makes sense to produce it under a name that is not associated with manufacturing illegal compounds...
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Would you be getting blood work with that from farafmansdorp clinic to determine level of shut down for you personally? How long will you run it for?I'm stacking 150mg SARMs with 8iu HGH and nothing else.
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admin wrote:
Would you be getting blood work with that from farafmansdorp clinic to determine level of shut down for you personally? How long will you run it for?I'm stacking 150mg SARMs with 8iu HGH and nothing else.
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Yes, I think everyone does...I would like to know what the gains are like
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Found this
www.sarmsinfo.com/
In your opinions what do you think shut down will be like with a drug like this?
Do you think this is something that could be done year round?
Would a drug like this not have better effects if used two weeks on two weeks off?
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