hey bud...hope this extract helps...
Centrophenoxine (Meclofenoxate)
A memory enhancer first used to treat Alzheimer's disease and senile dementia in the elderly. There's been a rush to raid the Alzheimer medicine cabinet, lately, in the hopes that what will make the senile keep their memory will make the healthy get even smarter, Centrophenoxine is the poster child of this movement. The chemical itself is a compound made from one naturally occurring substance--dimethylaminoethanol (DMAE)--and one synthetic, which is parachlorophenoxyacetate (pCPA). Exactly how it improves memory isn't known, but there are two leads: 1) it's a precursor to the neurotransmitter acetylcholine and may increase levels of it in the brain, and 2) it removes lipofuscin deposits in the brain and skin.
Lipofuscin on the skin lead to "liver spots", while its build-up in the brain is suspected to be behind the "plaques" that are observed in brain tissue samples taken from Alzheimer's patients. The theory for Alzheimers is that the lipofuscin clogs ion channels on the surface of nerve cells, preventing the movement of potassium through these channels and degrading memory and cognition in the process.
Centrophenoxine gave the author mild nausea when it was taken on an empty stomach, but not when taken with food. Avoid it completely if you suffer from high blood pressure or epilepsy. It's available over-the-counter from nutritional stores, but usually only those on the Internet. Like with the racetams and Sulbutiamine, I have not seen it in main-street nutrition stores.
Sulbutiamine
Is a stimulant as well as a memory enhancer. It's a chemical variant of vitamin B1, and the crucial difference is that it can cross the blood-brain barrier better than conventional B1 (thiamine). The B-family of vitamins tend to be stimulants because of their role in the metabolism of stored energy, and the more sensitive you are to stimulants such as caffeine, the more sensitive you're likely to be to the B vitamins, including Sulbutiamine.
creatine
An IQ booster. Creatine is already very popular with bodybuilders, and this makes it extremely easy and cheap to obtain. There are dozens of manufacturers and it's sold everywhere that dietary supplements are. It occurs naturally in your body and improves the supply of energy to your muscles. It has been found safe in doses of up to 20 grams per day, but there are known problems in those with kidney and liver disease, as well as those with diabetes or hypoglycemia. Add to that its tendency to increase the production of formaldehyde with long-term use. Its popularity with bodybuilders comes from giving them the ability to do more in a workout, leading to an increase of muscle tissue.
Its nootropic effects come from its effect on the production of Adinosine Triphosphate--the chemical energy that drives cellular activity. This makes it a type of stimulant, and in studies it was found to improve results in tests of fluid intelligence, which is the ability to find meaning in confusion, draw inferences, make symbolic connections, and solve problems. This is compared to crystalized intelligence, such as when you learn how to add, or tie your shoelaces. These studies were performed on vegetarians in order to isolate the effects of the supplement with natural creatine in meat.
Piracetam and Friends
A memory enhancer. The racetams ("ra-see-tam") are the first drugs to inspire the term Nootropic, and the trade-name for Piracetam is Nootropil. At the time of writing, their physical effect is believed to be similar to acetylcholinesterase inhibitors, meaning that it disables the action of an enzyme that deactivates a neurotransmitter called acetylcholine (see the next segment on Choline for more information). The judicial suppression of this enzyme can lead to greater memory retention and neural growth. Racetams now come in a large number of formulations, which although they vary at the molecular level, are all based on the same chemical theme and all have the same effect in different degrees. Those on the market are:
Choline
A memory enhancer, and the most basic of a class of substances called cholinergics. Choline is an essential nutrient that you get in your diet already, particularly from eggs, fish and chicken. Your body uses it in at least two places: cell membranes and the neurotransmitter acetylcholine. The first role has been found important for pregnant and post menopausal women, since pregnancy and low estrogen levels can drain the body's choline reserves. Its second role in neurotransmitters is what makes it a possible nootropic, since a 1975 study found that increased choline intake resulted in higher levels of acetylcholine in the brain, and acetylcholine is believed to be involved in the formation of memories.
Cholinergics cover a wider range of supplements that either act as a precursor to acetylcholine (an ingredient chemical needed to synthesize the neurotransmitter), or that modify the way your nervous system interacts with it. For example, an Acetylcholinesterase Inhibitor. Let's break down that mouthful of words:
Acetylcholine is a neurotransmitter, it bridges the gap between synapses when they're ready to "fire"
Acetylcholinesterase is an enzyme that "cleans up" acetylcholine, removing it from the synapse to reset it. Ie: it's anti-acetylcholine.
An acetylcholinesterase inhibitor is a chemical that interferes with acetylcholinesterase, preventing it from cleaning up the synapse. Ie: it's anti-anti-acetycholine
Rosemary, sage and marijuana are acetylcholinesterase inhibitors. For that matter, so is nerve gas and some types of snake venom. Mild inhibitors such as Huperzine A are being used to treat Alzheimer's disease, as it's suspected that the inhibition of the neurotransmitter stimulates nerve growth--a little bit like how you need to tear down muscle with exercize in order to make the body grow it back stronger.
This turns on the tape-recorder in your brain. It's also the most dangerous nootropic in the list because it interferes with homeostasis. Desmopressin is a synthetic analogue to the natural hormone vasopressin, which not only acts as a vasoconstrictor (shrinking the diameter of blood vessels) but also affects the hypothalamus and vastly improves memory formation. For nootropic use you need the nasal spray as to absorb the drug through the nasal membrane closest to the brain. Its effect is almost instantaneous and its users tend to take it immediately before lectures, conferences, and study periods. The effect can last for several hours and tends to leave one with a stronger recollection of the material studied while under its influence.
Do not take Desmopressin if you have high blood pressure. You may recall at the beginning of this article that I said these drugs would be listed in order of increasing risk. We're now at the end of the list and--if you pardon my language--you do not want to fuck with Desmo. I even placed it after smoking since it can kill you much faster and with fewer doses. Here's the deal:
A vasoconstrictor will increase your blood pressure
It will make your kidneys retain water, so another effect of Desmopressin is to reduce urine production (Desmopressin is commonly prescribed to prevent bedwetting)
Part of your body's homeostasis mechanism is to regulate blood water content by removing it--via the kidneys--into the bladder
Having too much water in your bloodstream can lead to electrolyte imbalance, and in severe cases this is called hyponatremia, or "water poisoning"
Hyponatremia is difficult to treat. If your doctors cannot control the rebalancing of your electrolytes, you may experience central pontine myelinolysis--nerve damage to the central pons area of the brain stem, which regulates autonomic functions such as breathing. Heart failure is also possible.
Use Desmopressin irresponsibly and you'll enjoy the rest of your life in an iron lung, unless you die before they can hook you up to one. If you remember the "Hold your wee for a Wii" contest held by a radio station, where a woman held her bladder for so long she died, know that she died of hyponatremia--the same malady that can be caused by the wrongful use of this drug.
If you were to take Desmopressin then you must avoid heavy exercise and the excessive consumption of liquids for at least 6 hours afterwards. Do not drink sport drinks such as Gatorade or Powerade. Drink only when thirsty and only until you're no longer thirsty.
Modafinil was first prescribed to narcoleptics to help them stay awake during the day, and then used by the Navy and Air Force to help pilots stay alert on long missions. Modafinil keeps you awake and alert, has an effectiveness that spans up to 8 hours, increases the capacity of your working memory, and is the closest thing you can get to the fictional NZT-48 from the movie Limitless. It remains prescription-only in the United States, and any US resident would need to either obtain a prescription from a doctor, or purchase it from a foreign supplier.
Modafinil increases the level of dopamine in the brain, and is therefore potentially addictive. I will go out on a limb to say I've not developed an addiction to it, in spite of taking it frequently, but this is only my experience. Do not take Modafinil if you have cirrhosis of the liver or heart disease, and do not mix it with alcohol.
Because this list is given in order of increasing risk, I'll point out that Modafinil is our turning point between unregulated "nutritional supplements" and drugs that are powerful enough to stay behind the counter. From Modafinil and onwards in this list, you will not want to take these if you are pregnant, breastfeeding, or have not received a physical exam from a doctor in the past year.
Modafinil is broken down by the liver enzyme CYP 3A4, and 3A4 itself is inhibited by the naturally occurring chemicals found in grapefruit juice. Doctors who prescribe Modafinil therefore warn their patients against drinking grapefruit juice while they're on the medication (and as it happens, many other drugs are broken down by 3A4 and are similarly affected). Given that Modafinil has low overdose potential, the author tried deliberately taking it with grapefruit juice but did not perceive a change in effect.
Modafinil can promote wakefulness without the jitters of caffeine, and under the right conditions can let you stay awake for 48-hours without feeling excessively sleepy. But taking it doesn't mean you'll suddenly be fatigue-free and spend the next two days wide awake; Modafinil--used as a nootropic--helps those who already have a good sleep pattern. The author was not able to dispatch sleep by popping a few pills, but he was able to perform and concentrate superbly under its influence for hours at a time.
Take about 100mg for every 100lbs of body weight, anything less and you won't feel much of a difference. If you take the right dose then in about an hour you'll start to feel a subtle buzz, like someone swapped the battery in your brain with one that has a higher voltage. Take the first dose in the morning, and--if necessary--a second dose in the afternoon. While some have used it to pull all-nighters, you can't use it to eliminate sleep--there's no drug which can do that. Nor should you take it every day for nootropic use, because your body will adjust and require higher doses to get the same effect. My practice is to use it no more than once a week on a day that I've set aside for an important project.
If you want to take it for nootropic effect then don't take it when you feel tired, because while it will lift you out of your stupor it will just be an expensive way to get the same effect as a nap and a cup of coffee.
sorry for the posts untidiness, kinder did it in a hurry..and if i included any links or price, please delete the post admin.
Topic Author
Have been doing this for 6 years now so I know a trick or two. Why don't you try and explain your situation a bit more then I will try to help you as much as I can? 
