Good day buds
Anyone have experience with Ractopamine? It is the active ingredient in Paylean, and causes piglets to shed fat and add extra lean mass. A friend told me about this- they used it for pigs in Texas. He told me it is very expensive but he couldn't believe the changes that happened in the pigs. He said in just a couple of weeks they changed from fat and obese pigs to lean mean muscle machines, without much training. He said the only exercise they had was a little walking once a week.
I was just wondering.... :whistle:
This is copied from various websites:
After roughly a decade of research and evaluation, the U.S. Food and Drug Administration has approved the feed additive ractopamine for use in finisher phase swine feeds. The product was developed and will be marketed by the Elanco Animal Health Division of the Eli Lily Company. The trade name for the product is PayleanTM. The product is now commercially available through feed ingredient suppliers and certain animal health product dealers.
The active ingredient in PayleanTM, ractopamine hydrochloride, is a member of a group of compounds called beta-adrenergic agonists. These compounds are synthetic analogues of noradrenaline and adrenaline, which are hormones that impact energy and fat metabolism in the body. In pigs and other meat animals the principle effect of ractopamine is to redirect energy and nutrients away from fat deposition and toward lean (muscle) tissue deposition. Supplementation of the diet with 9 to 18 grams of ractopamine per ton during the last 4 to 5 weeks before slaughter results in improvements of up to 9% in growth rate and 13% in feed efficiency. Carcass effects are even more striking with backfat depth reductions of up to 12% and loin muscle area increases of up to 14%. Because ractopamine increases protein deposition in pigs, the product label indicates that any swine feed to which ractopamine is added should contain at least 16% protein. The approved label allows the addition of 4.5 to 18 grams of active ingredient per ton of complete feed. It is only approved for market hogs from 150 to 240 pounds of body weight. There is no pre-slaughter withdrawal period required for Paylean.
From Wikipedia:
Ractopamine is a drug that is used as a feed additive to promote leanness in animals raised for their meat. Pharmacologically, it is a beta-adrenoceptor agonist. It is the active ingredient in products known as Paylean for swine and Optaflexx for cattle, developed by Elanco Animal Health, a division of Eli Lilly and Company, for use in food animals for growth promotion.
Mode of action
When used as a food additive, ractopamine added to feed can be distributed via the blood to the muscle tissues, where it will bind to specific beta receptors in the muscle cell membranes. A cascade of events will then be initiated to increase protein synthesis, which results in increase in muscle fiber size. Ractopamine is known to increase the rate of weight gain, improve feed efficiency and increase carcass leanness in finishing swine. Its use in finishing swine yields about three kilograms of additional lean pork and improves feed efficiency by 10%. In steers and heifers, ractopamine use increases hot carcass weight by about 5.5 kilograms and 5 kilograms, respectively.
Comparison to clenbuterol
Similar to ractopamine, clenbuterol is a growth promoting compound belonging to the beta-agonist family. It is known to have the effect of enhancing weight gain and proportion of muscle to fat. However, clenbuterol is known to have a much longer half-life in blood than ractopamine and thus has a greater potential for bioaccumulation.
Clenbuterol is reported to induce unintended side effects on humans, such as increased heart rate, muscular tremors, headache, nausea, fever, and chills. The US FDA has concluded these side effects to be unacceptable. The use of clenbuterol in food animals has been prohibited in almost all countries, including the USA, Canada, Taiwan, Hong Kong. In contrast, ractopamine is allowed to be used at the recommended concentrations in food animals for growth promotion in some countries such as the United States, Canada, Australia.
Cardiovascular effects
Dose-dependent changes of heart rate and cardiac output are observed within the first hour after administration of ractopamine and gradually return to baseline values. The systolic blood pressure will also increase in a dose-dependent manner, while the diastolic pressure remains unchanged.
Pharmacokinetics in humans
A study was conducted to define the pharmacological response of humans to ractopamine. A single oral dose of 40 mg of ractopamine hydrochloride was given to human volunteers. Ractopamine was rapidly absorbed. The mean blood plasma half-life was around 4 hrs and ractopamine was not detected in plasma 24 hrs after dosing. It was shown that <5% of total ractopamine excreted represented the parent drug, while the urinary metabolites were monoglucuronide and monosulfate conjugates, with ractopamine monosulfate being the major metabolite present.[9]
The metabolic fate of ractopamine hydrochloride is similar in the target species (pigs and cattle), laboratory animals and humans. Besides the pharmacology effect, ractopamine may cause intoxication effect, therefore, any consumption by humans of a meat and/or byproducts of animals that consumed ractopamine with feed for growth stimulation, may result in such clinical effects as tachycardia and other heart rate increases, tremor, headache, muscle spasm, high arterial blood pressure.[10] The effect of ractopamine on humans is not entirely known, but consumption of products that contain ractopamine leftovers is not advisable to people with CVD (cardiovascular diseases).
I have not read up on everything I could get. But was just wondering. If it works for pigs it should work for humans right? There are actually a couple of BB sites mentioning Ractopamine but it seems like there are not a lot of guys like Yomhimbe who test and post their logs :lol:
I would love to hear the feedback from the more experienced guys
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