Phosphatidyl Serine aka (PS) has been shown to significantly reduce (suppress) the destructive hormone cortizone. Unlike the pharmaceutical drug Aminoglutamide that is a cortizol blocker, preventing the body from manufacturing significant levels of cortizone which in turn is very dangerous. PS is perfectly safe and has many other interesting benefits on brain function. It is an expensive compound to use and its not as yet offered in the correct dosage for cortizol suppressing purposes...
direct quote from doctari
"Have used this on and off the last 12+ months. It is also known as one of the "smart drug" compounds - it assists in preventing memory loss and some even propose it to be an alternative treatment to Alzheimers. The dosages for preventing memory loss, ranges from 150-250mg per day, but it is a very effective cortisol suppressor at dosages of 800mg per day. At such high dosages, it is preferred not to be used longer than 4-6 weeks at a time - it's unsafe to permanently try and suppress cortisol levels. I always incorporate it as a standard in my PCT protocols at 800mg p day x 4 weeks."
From another site.
In addition to the effect on memory, phosphatidylserine reduces circulating levels of the stress hormone cortisol. In one study, healthy men were given 800 mg phosphatidylserine for 10 days and the release of cortisol and ACTH in response to physical exercise was blunted, suggesting that phosphatidylserine counteracted the stress-induced activation of the hypothalamo-pituitary-adrenal axis [11]. In another study, IV administration of BC-PS was compared with placebo, and it blunted the ACTH and cortisol response to bicycle ergometer exercise [12]. Finally, a double-blind cross-over study on 11 male subjects undergoing intensive weight training for two weeks found that 800 mg of S-PS decreased post-exercise cortisol levels and reduced the muscle soreness and psychological depression associated with overtraining [13]. This indirectly indicates that phosphatidylserine administration could improve athletic performance by reducing the detrimental effects associated with overtraining.
Related to the effect on cortisol is the effect phosphatidylserine has on stress and depression. One study was done in young adults with neuroticism scores above the median, in which 300 mg of phosphatidylserine was administered for one month and associated with less feelings of stress and an overall better mood [14]. A study in elderly women with major depressive disorders found only 200 mg daily of phosphatidylserine to cause a significant improvement in depressive symptamology [15]. Phosphatidylserine also has a potent anti-stress effect in animal models – in rats, it prevented restraint-induced hyperthermia and decreased incidence of gastric ulcers from restraint-plus-cold treatment [16].
www.lef.org/magazine/mag2004/jul2004_report_cortisol_02.htm
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