Hexapeptide GnRH Questions

Hey, just a thing or two on GnRH:

I would be correct in saying its an intramuscular injection?
Stored at room tempreture?
Half life is a couple of hours so its out in a minimum of 48hrs?

Thanks.

Perhaps this would help:
I have scribbled out all details on the vial.

Be careful. It's not something to mess with and it does not help recovery long term like it is hyped to. In high doses they use it to chemically castrate serious sex offenders because it severely downregulates GnRH receptors in the pituitary. It's also given to cancer patients who have tumours that are aggrevated by androgens who need to stop all testosterone production.

The initial dose does cause a pretty much instant huge release of LH and FSH and you feel great because of the resulting natural test boost. But at the same time the number of receptors for GnRH to bind to in the pituitary are reduced drastically so after the initial boost there is a big temporary drop in response to SERMS and GnRH. If you're on clomid/nolva the average guy really has no need for this stuff. Always keep triptorelin to only one dose only.

It has it's uses but generally should only be used in severe cases of secondary hypogonadism if nothing else seems to work.

Sex offenders hey? Then its just up my alley LOL
Thanks MA, thats a wealth of info:
Should i mention how i was planning on using it or will that create drama?

Why are you wanting to use it Bud?

Moer that kak away, it's playing with fire.

FIllet wrote: Should i mention how i was planning on using it or will that create drama?

Let's hear it, and where you heard it from?

Makes me sceptical with what MA and Boss say, should i perhaps mail you Admin; you can then share with MA and tell me what you think?

When these boys say no, its a no go bud.

All good gents, got the info from a sports doctor...

He did mention its dangerous if you shoot up more then 3 times per year but in the plan was only to shoot up once. PCT would follow out as per normal, there would just be a little timing between the last hcg shot, the GnRH shot and the clomid, nolva, aromasin.

And thanks for the heads up fellows.

Here is a very old reply Doc sent me about similar products a couple of years ago.

Admin,

Here follows a short reply to the question..

Triptorelin, as far as my knowledge, is no longer available in South Africa. It has been replaced by the GnRH analogues Buserelin ( Suprefact by Sanofi), Goserelin (Zoladex by AstraZeneca) and Leuprorelin (Lucrin by Abbott Labs). Buserelin and Leuprorelin are indicated in the use of advanced prostatic cancer, where total suppression of testosterone is needed - hence the dosages range from 9,9 milligrams to 11,25milligrams - read medical "castration" levels. Zoladex is indicated for advanced breast cancer, also at high dosages.

I've known about the GnRH analogues for many years. So, why have I not used it as PCT? Simple answer - your HPT-axis is a very sensitive system. Once you have buggered it up, it won't rebound. I designed my PCT protocol specifically to hit the testicular level and NOT stimulate the HP-part of the axis directly. The latter is the most sensitive part of the axis. You have to be extremely careful of dosaging stimulating these sensitive glands directly. With my protocol, even if it takes longer than that "shortcut one-shot" everybody is always looking for, the HP -part is stimulated by physiological levels of hormone production from the testii. Then, also remember why I prefer Ovidrel above HCG. Ovidrel, being only the alpha-subunit of the HCG molecule, binds to three different receptors - FSH, LH and TSH. Why do I prefer to use the Clomids first? Studies have shown it to "prime" the testii for the first LH response. That initial testosterone response after the Clomid and first LH surge, will lead to high testosterone production, which will easily estrogenize. These high estrogen levels then again will suppress the HP-axis part - that's why tamoxifen is used to counter-act this estrogen production in the testii.

I prefer this protocol and not to use protocols of hormonal stimulation directly to the HP-axis. I leave this sophisticated stimulation to Endocrinologists that perform these interventions in a very controlled enviroment. And the average b/builder that injects himself at home, is definitely not the "controlled enviroment" I'm referring to here..

I have followed a group of athletes (elite level b/builders in RSA) over the last 2 years as part of my research for my Masters Degree. All of them follow my protocol on PCT and I have followed these guys up after their respective PCT's were finished - none have not responded adequately to my PCT protocol. The average weightloss post -cycle was less than 10% once the PCT was finished. All of them rebounded their HPT-axii successfully with the minimum loss in physical conditioning.

Then, on the subject of on-cycle HCG stimulation, I never was a believer in this, as it physiologically does not make sense to me. If you show me the research studies that prove otherwise, it might "re-educate" me to better knowledge.. And please don't show me anecdotal stuff or research done in animal models.

Just to re-iterate - I'm very weary of direct stimulation to the Hypothalamus-Pituary gland.

Regards
Doctari.

The above discussion is very old, so opinions on PCT, Ovidrel ect have changed since then, but the part about the GnRH still stands in my opinion.

Shot Boss. Plus some karma!