CJC1295 and GHRP6

Here is a nice summary of GHRP6 and CJC for release of GH and how it works leading on from the "hgh by itself" thread

Author is DATBTRUE

Brief overview of natural GH release

The initiation of growth hormone release in the pituitary is dependent on a trilogy of hormones:

Somatostatin which is the inhibitory hormone and responsible in large part for the creation of pulsation;

Growth Hormone Releasing Hormone (GHRH) which is the stimulatory hormone responsible for initiating GH release; and

Ghrelin which is a modulating hormone and in essence optimizes the balance between the "on" hormone & the "off" hormone. Before Ghrelin was discovered the synthetic growth hormone releasing peptides (GHRPs) were created and are superior to Ghrelin in that they do not share Ghrelin's lipogenic behavior. These GHRPs are GHRP-6, GHRP-2, Hexarelin and later Ipamorelin all of which behave in similar fashion.

In the aging adult these Ghrelin-mimetics or the GHRPs restore a more youthful ability to release GH from the pituitary as they turn down somatostatin's negative influence which becomes stronger as we age and turn up growth hormone releasing hormone's influence which becomes weaker as we age.

The exogenous administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of GH release which will be small if administered during a natural GH trough and higher if administered during a rising natural GH wave.

Growth Hormone Releasing Peptides (GHRP-6, GHRP-2, Hexarelin) are capable of creating a larger pulse of GH on their own then GHRH and they do this with much more consistency and predictability without regard to whether a natural wave or trough of GH is currently taking place.

Synergy of GHRH + GHRP

It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and a Growth Hormone Releasing Peptide (GHRP-6, GHRP-2 or Hexarelin) results in synergistic release of GH from pituitary stores. In other words if GHRH contributes a GH amount quantified as the number 2 and GHRPs contributed a GH amount quantified as the number 4 the total GH release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 10.

While the GHRPs (GHRP-6, GHRP-2 and Hexarelin) come in only one half-life form and are capable of generating a GH pulse that lasts a couple of hours re-administration of a GHRP is required to effect additional pulses.

Growth Hormone Releasing Hormone (GHRH) however is currently available in several forms which vary only by their half-lives. Naturally occurring GHRH is either a 40 or 44 amino acid peptide with the bioactive portion residing in the first 29 amino acids. This shortened peptide identical in behavior and half-life to that of GHRH is called Growth Hormone Releasing Factor and is abbreviated as GRF(1-29).

GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).

To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately & confusingly mislabeled as CJC-1295. If you prefer analogies think of this as a Testosterone Propionate (i.e. short-estered).

Note that some may also refer to this as CJC-1295 without the DAC (Drug Affinity Complex).

Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29) is required and as previously indicated works synergistically with a GHRP.

In an attempt to create a more convenient long-lasting GHRH, a compound known as CJC-1295 was created. This compound is identical to the aforementioned modified GRF(1-29) with the addition of the amino acid Lysine which links to a non-peptide molecule known as a "Drug Affinity Complex (DAC)". This complex allows GRF(1-29) to bind to albumin post-injection in plasma and extends its half-life to that of days. If you prefer analogies think of this as a Testosterone Cypionate (i.e. long-estered). However this is not accurate. CJC-1295 results in continual GH bleed. Although natural pulsation still occurs CJC-1295 does nothing to increase those pulses. Instead it raises base levels of GH and creates a more feminized pattern of release. This not desirable.

Modified GRF(1-29)however when combined with a GHRP brings about a substantial pulse which has desirable effects.

Dosing GHRPs

The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin side-effects.

Ipamorelin is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range.

GHRP-2 is a little more efficacious then GHRP-6 at causing GH release but at the saturation dose or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing an increase in GH release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal.

Desensitization

GHRP-6 can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 probably at saturation dose several times a day will not result in desensitization.

Hexarelin has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these GHRPs simply stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed several times a day every day will not cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) all are basically GHRH and have a short half-life in plasma because of quick cleavage between the 2nd & 3rd amino acid. This is no worry naturally because this hormone is secreted from the hypothalamus and travels a short distance to the underlying anterior pituitary and is not really subject to enzymatic cleavage. The release from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

However when injected into the body it must circulate before finding its way to the pituitary and so within 3 minutes it is already being degraded.

That is why GHRH in the above forms must be dosed high to get an effect.

GHRH analogs

All GHRH analogs swap Alanine at the 2nd position for D-Alanine which makes the peptide resistant to quick cleavage at that position. This means analogs will be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or referred to by me as modified GRF(1-29) has other amino acid modifications. They are a glutamine (Gln or Q) at the 8-position, alanine (Ala or A) at the 15-position, and a leucine (Leu or L) at the 27-position.

The alanine at the 8th position enhances bioavailability but the other two amino substitutions are made to enhance the manufacturing process (i.e. create manufacturing stability).

For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide with a half-life probably 30+ minutes.

That is long enough to be completely effective.

The saturation dose is also defined as 100mcg.

Problem w/ Using any GHRH alone

The problem with using a GHRH even the stronger analogs is that they are only highly effective when somatostatin is low (the GH inhibiting hormone). So if you unluckily administer in a trough (or when a GH pulse is not naturally occurring) you will add very little GH release. If however you luckily administer during a rising wave or GH pulse (somatostatin will not be active at this point) you will add to GH release.

Solution is GHRP + GHRH analog

The solution is simple and highly effective. You administer a GHRH analog with a GHRP. The GHRP creates a pulse of GH. It does this through several mechanisms. One mechanism is the reduction of somatostatin release from the hypothalamus, another is a reduction of somatostatin influence at the pituitary, still another is increased release of GHRH from the brain and finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a way of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH is not additive it is synergistic. By that I mean:

If GHRH by itself will cause a GH release valued at 2
and GHRP itself will cause a GH release valued at 5

Together the GH is not 7 (5+2) it turns out to say 16!

A solid protocol

A solid protocol would be to use a GHRP + a GHRH analog pre-bed (to support the nightime pulse) and once or twice throughout the day.

For anti-aging, deep restful restorative sleep, the once at night dosing is all you need. For an adult aged 40+ it is enough to restore GH to youthful levels.

However for bodybuilding or fatloss or injury repair multiple dosings can be effective.

The GHRH analog can be used at 100mcg and as high as you want without problems.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg will probably be fine as well.

Again desensitization is something to keep an eye on particularly with the highest doses of GHRP-2 and all doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together will be effective.

This may be dosed several times a day to be highly effective.

A solid approach is a bit more conservative at 100mcg of GHRP-6 + 100mcg of a GHRH analog dosed either once, twice, three or four times a day.

When dosing multiple times a day at least 3 hours should separate the administrations.

The difference is once a day dosing pre-bed will give a youthful restorative amount of GH while multiple dosing and or higher levels will give higher GH & IGF-1 levels when coupled with diet & exercise will lead to muscle gain & fatloss.

Dose w/o food

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 minutes (no more then 30 but no less then 15 minutes) to eat. AT that point the GH pulse has about hit the peak and you can eat what you want.

nice one bro, have some karma for top notch info...

Thanks for the post, but from my understanding Hexarelin is the better of these peptides and the above article also seem to suggest that? Why do people use CJC1295 and GHRP6 when they can just take Hexarelin?

Ah yes I remember reading this article a while back.
Don't remember it that well, but just skimming it now again and it suggests the preference for GHRP6 over hexarelin is down to less side effects and down reg? Or maybe availability. I know many guys that can only exclusively get GHRP2.

The combination though of GHRP and CJC is definately preferred to hexarelin alone for their synergy if that is more the question.

Great post yohimbe!

Thanks for that one, just one question. Would ghrp-6 on its own also be ineffective?

It says dosing administrations should be minimum 3 hours apart, what would the maximum be?

And in your opinion when would be better to shoot the cjc1295 and ghrp6 mixture, pre or post workout?

Thanks bud have some karma

admin wrote: Thanks for the post, but from my understanding Hexarelin is the better of these peptides and the above article also seem to suggest that? Why do people use CJC1295 and GHRP6 when they can just take Hexarelin?

Hexarelin is the same group of peptides as GHRP whereas cjc is GHRH, so hexarelin can be used as replacement of GHRP6 but still needs to be used a GHRH (cjc) to capitalize on the synergy of using GHRP and a GHRH for maximun gh release

Hexarelin is more efficient than GHRP6 at producing GH, but as Inja says the sides are greater-can increase cortisol and prolactin and also causes desensitization very quickly-14 days at saturation dose of 100mcg

Probably also to do with supply-GHRP6 and GHRP2 seem to be the most common

At Gorilla-GHRP6 by itself isn't ineffective, just there is a synergistic effect when used with cjc.
I would say post workout is probably best, but the most important time to use it is before bed

There is no maximum period apart-as a anti aging peptide its used once per day just before you go to bed. So can use it once per day or several times per day, just needs to be three hrs apart to allow the pulse to return to baseline

thanks for the karma

This study * caught my attention because it examined the pharmacokinetics of GHRP-2 and in so doing compared it to synthetic GH administration.

Basically they found 1mcg/kg of GHRP-2 half as effective as 43mcg/kg of synthetic GH...they found a linear relationship and therefore they conjectured that 2mcg/kg of GHRP-2 would be as effective as 43mcg/kg of synthetic GH.

However the studies participants were prepubescent children of short stature so we should use their weights. Googling revealed that 40lbs would be a decent approximation of such a young undersized male child. That converts to about 18 kilograms.

For synthetic GH that would mean the children received 43mcg * 18kg = 774mcg of GH.

Nutropin reveals that 1 iu of their GH is equal to 333 mcg so that equates to aproximately 2.3iu of GH.

For GHRP-2 that would mean the children received 1mcg * 18kg = 18mcg of GHRP-2.

Using the studies statement that 2mcg/kg of GHRP-2 equalled the synthetic GH dose we arrive at 2mcg * 18kg = 36mcg of GHRP-2 equally 2.3iu of synthetic GH...or further extrapolation 100mcg of GHRP-2 approximately = 6iu of synthetic GH.

I think the above extrapolation is too liberal for adults & thus flawed. So lets be real conservative in our approach and recognize that the studies used saturation doses (1mcg/kg). For adults I would like to stick with the definition of saturation dose of 1mcg/kg... and use that for adults so for a 100kg man that equals 100mcg of GHRP-2. That would mean a single 100mcg dose of GHRP-2 would equal 1.15iu of synthtic GH.

All this approach assumes is that the saturation dose for children produced the equivalent of 1.15iu of synthetic GH therefore the saturation dose for adults will do the same.

So 3 100mcg doses of GHRP-2 per day will conservatively equate to (1.15 x 3) about 3.5iu of synthetic GH. Note that if the average weight of the study children were really 50 pounds then this 3.5iu estimate becomes 4.2ius of synthetic GH.

So it is probably not unrealistic to figure that 100mcg of GHRP-6 dosed three times a day will yield the approximate equivalent of 3.5 to 4 ius of synthetic GH per day in a young adult male.

* Pharmacokinetics and Pharmacodynamics of Growth Hormone-Releasing Peptide-2: A Phase I Study in Children Catherine Pihoker, Gregory L. Kearns, Daniel French and Cyril Y. Bowers, The Journal of Clinical Endocrinology & Metabolism 1998 Vol. 83, No. 4 1168-1172

Abstract

Administration of GH-releasing peptide-2 (GHRP-2) represents a potential mode of therapy for children of short stature with inadequate secretion of GH. Requisite information to determine the dosing route and frequency for GHRP-2 consists of the pharmacokinetics (PK) and pharmacodynamics (PD) for this compound, neither of which have been previously evaluated in children. The purpose of this study was to characterize the PK and PD of GHRP-2 in children with short stature. Ten prepubertal children (nine boys and one girl; 7.7 ± 2.4 yr old) received a single 1 µg/kg iv dose of GHRP-2 over 1 min, followed by repeated (n = 9) blood sampling over 2 h. GHRP-2 and GH were quantitated by specific RIA methods. PK parameters were calculated from curve fitting of GHRP-2 and GH vs. time data. Posttreatment plasma GH concentrations (normalized for pretreatment values) were used as the effect measurement....

Discussion

The pharmacokinetics of GHRP-2 found in our cohort of pediatric patients are similar to those previously reported in healthy adult volunteers after iv administration of the peptide (3). A comparison of the maximum GH response observed after GHRP-2 administration between these two studies revealed similarities in both the magnitude (i.e. mean values = 44 µg/L in children vs. 55 µg/L in adults) and time of maximal response (i.e. average values = 45–60 min for both). The GH responses observed after iv or sc GHRP-2 are also similar to those previously reported after the parenteral administration of GHRP-6, GHRP-1, or GHRH (3, 4, 23, 24).

To our knowledge, our data represent not only the first report of GHRP-2 pharmacokinetics in pediatric patients, but also the first pharmacodynamic assessment of this peptide. Comparison of the serum concentration vs. time profiles for both GHRP-2 and GH in our subjects reveals an equilibration delay in the attainment of peak GH response, a period that we believe corresponds to the time course of GHRP-2 action. This assertion is supported in part by the consistent observation of an equilibration delay between the serum concentrations of GHRP-2 vs. effect (i.e. change GHt) curves, reflected by the production of a counterclockwise hysteresis and our success in using the sigmoid Emax model to effectively determine the pharmacodynamic parameters for GHRP-2. As previously reported by Holdford and Sheiner (22), the successful application of this pharmacodynamic model suggests both linearity and predictability in the drug concentration vs. effect relationship. Given the fact that GH is a proximate biological marker of GHRP (and presumably, GHRP-2) activity (23, 24), our assumptions entailed in the pharmacodynamic analysis of our data appear valid and reflective of the expected pharmacological response of GHRP-2.

Despite the apparent differences in serum GH pharmacokinetics reported after exogenous administration of the hormone (25) as opposed to the administration of GH secretagogues (26, 27, 28, 29, 30), both the pharmacokinetic and pharmacodynamic data from our study can be used to address the potential therapeutic efficacy of GHRP-2 in pediatric patients with GH insufficiency. First, the mean AUC for GH after the iv administration of a single 1 µg/kg dose of GHRP-2 (i.e. 50.7 ng/mL·h) was approximately 50% of the AUC at steady state (i.e. 114.2 ± 32.7 ng/mL·h) previously reported in a study of pediatric patients who received daily sc doses of 43 µg/kg methionyl GH (25). If one assumes linearity in the dose-response relationship for iv GHRP-2, administration of a single 2 µg/kg iv dose would be expected to produce an AUC for GH that would be virtually identical to that observed under steady state conditions after sc administration of the currently recommended daily doses of recombinant human GH (25), doses that have been shown to produce acceptable rates of linear growth in children who are GH deficient (30). Second, both the Cmax (mean, 50.7 ng/mL) and Emax values for GHRP-2 in our patient cohort (mean GH, 67.5 ng/mL) actually exceeded the average Cmax values for GH (37.6 ± 11.6 ng/mL; range, 17.6–49.5 ng/mL) after a single sc dose of 0.1 mg/kg methionyl GH to GH-deficient children (25). Finally, the EC50 for GHRP-2 in our study cohort (1.1 ± 0.6 ng/mL) was substantially less than the Cmax value (7.4 ± 3.8 ng/mL). This particular finding not only supports the adequacy of the 1 µg/kg iv dose of GHRP-2 in producing a desirable biological effect, but also suggests that extravascular administration of this peptide by a route that could be associated with up to a 50% reduction in bioavailability may still produce an acceptable increase in the serum GH concentration sufficient to initiate and sustain a desired growth response. This hypothesis is being tested by our group in dose-ranging studies of oral and intranasal GHRP-2 that are currently underway.

In conclusion, both the pharmacokinetics and pharmacodynamics of iv administered GHRP-2 in short children are predictable and reflective of the potential for therapeutic application of this peptide. The data produced in this investigation will enable the selection of GHRP-2 doses for future evaluation of their bioavailability, safety, tolerance, and efficacy in children.

Yohimbe would there be any benefit of stacking hexarilin and ghrp-2 with cjc?

I wouldn't have thought so because both GHRP2 and hexarelin are both GHRP. The benefit comes from stacking a GHRP with GHRH (cjc) and would have thought saturation levels would be reached stacking two GHRP's, but will do some reading and see if I can find anything on it

From what I've found it doesn't seem there's much benefit stacking two GHRP unless you haven't reached maximum saturation of the GHS receptors
This is exert from the guy who wrote the initial article who's done a lot of research on the GHRP and GHRH

I don't do this often but I was asked about the following claim by a peptide seller.

Hexarelin is a six-amino acid peptide. Studies have shown that hexarelin is actually more effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide combination is created than ever heard of.

If you have read my thread you'll know that there is a lot of error in this marketing phraseology.

The second line is worthless. There is no need to compare a GHRP w/ a GHRH. All GHRPs (not just Hexarelin) are more effective then GHRH ...but so what?

The third line is correct that GHRH (Growth Hormone Releasing Hormone) has a synergistic effect w/ any Ghrelin mimetic. Ghrelin mimetcs are also called GHS (Growth Hormone Secretagogues) and come in the form of peptides (GHRP-6, GHRP-1 (don't ask), GHRP-2, Hexarelin, Ipamorelin, and many other derivatives) as well as smaller molecules that were developed & studied for potential oral & nasal delivery such as MK-677 & many derivatives of Ipamorelin.

GHRH is one class of hormone & GHRPs (including Hexarelin & GHRP-6) are another class of hormone derivatives (i.e. based off of Ghrelin).

You choose one of the the GHRHs (Sermorelin, modified GRF(1-29) [also called CJC w/o the DAC, or CJC-1295] AND one of the GHRPs (GHRP-6, Hexarelin, GHRP-2, etc.) and get synergy.

The last line of the marketing is just wrong. There is no synergy between any members of a class. Synergy comes from combining a member from each class.

Obviously you can use Hexarelin and GHRP-6 together to fill up the GHS-receptors or just use one or you could use 50mcg of Hexarelin, 50mcg of GHRP-2, 50mcg of GHRP-6, 50mcg of Ipamorelin and all this does is fill up you GHS-receptor slot. Do I need to go on?

@Yohimbine - My suppliers cant source CJC w/o. He says that he has been using CJC w DAC for 8 months and recommends that i use 20 units of CJC twice a week and then stop after 10 weeks and take a 5 weeks break and stop again after 5 weeks etc...

According to him a GH bleed can only become an issue after 10 weeks, or he might just be saying this cause he cant source CJC w/o DAC.
Do you think i must look for another supp?

@andre the cjc w/o DAC is also called sermorelin ask your source if he can hook you up with that

Tippster wrote: @andre the cjc w/o DAC is also called sermorelin ask your source if he can hook you up with that

Nope, not quite the same. Sermorelin is similar to cjc w/o DAC. They have different half lives. Cjc w/o dac is a modified more effective form of sermorelin because the half life is about 3x longer.

@tipster. Nope, is it reallu that much better to run without dac comparred to with?

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andre300 wrote: @tipster. Nope, is it reallu that much better to run without dac comparred to with?

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CJC with dac will cause gh bleed-gh is released in pulses naturally and thats the reason for running it w/o dac to mimick the natural pulses.

This isn't ideal, you want to mimic the body with gh pulses as GH converts to IGF and a constant GH bleed will cause constant conversion which in turn inhibits MGF and release of somatostatin = stopping further gh release.

CJC with dac is how female releases gh

Then i dont know what to do as supp cant get w/o dac. What about cycling the cjc w dac?

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andre300 wrote: Then i dont know what to do as supp cant get w/o dac. What about cycling the cjc w dac?

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What is the cycle you want to run?
CJC on its own is fairly weak-and the timing is very important and impossible to tell-thats why you need to use it with a GHRP

Yohimbe wrote:

andre300 wrote: Then i dont know what to do as supp cant get w/o dac. What about cycling the cjc w dac?

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What is the cycle you want to run?
CJC on its own is fairly weak-and the timing is very important and impossible to tell-thats why you need to use it with a GHRP

Looking at the following:
Week 0 - 24 ghrp 6 & cjc, 500mcg a day, split in AA and PM (at this point it will be with DAC, as i cant get w/o
I want to do test prop for 10 weeks, but i am not sure if i should do it in start middle or end of the ghrp 6 cycle

When i say cycle the cjc, i mean like once a week or twice a week as i cant get hold of cjc w/o dac.

Yohimbe can you just double check my injection protocol for me please bud?

6:00: 100mcg GHRP-6
6:30: Protein+carbs+fat meal

8:30: Shake with whey and pb

10:30: 100mcg ghrp6
11:00: Protein+carbs+fats meal

12:30: Protein+carbs+fat meal

13:45-14:00 Carb meal PRE WO

16:30: 100mcg ghrp6 POST WO
16:50: Carbs+protein meal

20min pre-supper another shot of ghrp6 between 6-7pm

21:00 100mcg ghrp6 + 5g GABA

22:00 Whey and Peanut Butter (bedtime)

Thanks bud.

The main side effect from gh bleed seems to be Acromegaly, which i dont want to play with as it can get nasty. Think i'll just hang tight till i have found a supplier that can get me the correct cjc.

But will still like feedback on this cycle

Just leave out the CJC w DAC andre, 500mcg of ghrp6 should equate to about 5-6ius of GH release. Just keep in mind the saturation dose is 100mcg so thats 5 shots a day! :pinch:

I did not take the saturation into account at all and i wont be able to pin 5 times a day that means my planned protocol of 250 mcg twice a day would have been a huge waste. Seems i am gonna have to go the gh route as it will suit my life style more.

What will the gh yield be on 300 mcg a day?

3x 100mcg shots per day will yield about 3.5-4 iu's of GH in a young male.

All this info I got from another site, same site yohimbe quoted the first post from. Dont know if im allowed to post it, but I will if I get the go-ahead from mods??

Mods?

andre300 wrote: I did not take the saturation into account at all and i wont be able to pin 5 times a day that means my planned protocol of 250 mcg twice a day would have been a huge waste. Seems i am gonna have to go the gh route as it will suit my life style more.

What will the gh yield be on 300 mcg a day?

You could bump the dose to 150mcg per shot-you'll lose a little absorption on the extra 50mcg but will still get most of the yield

That way pin 150mcg fist thing in the morning, 150mcg when you get home from work and 150mcg just before you go to bed, just make sure you haven't eaten for about 1-1.5hrs before the shot and for 20-30min after.

That should give you reasonable gh yields

gorilla wrote: Yohimbe can you just double check my injection protocol for me please bud?

6:00: 100mcg GHRP-6
6:30: Protein+carbs+fat meal

8:30: Shake with whey and pb

10:30: 100mcg ghrp6
11:00: Protein+carbs+fats meal

12:30: Protein+carbs+fat meal

13:45-14:00 Carb meal PRE WO

16:30: 100mcg ghrp6 POST WO
16:50: Carbs+protein meal

20min pre-supper another shot of ghrp6 between 6-7pm

21:00 100mcg ghrp6 + 5g GABA

22:00 Whey and Peanut Butter (bedtime)

Thanks bud.

Looks good to me Gorilla-good luck bud and let me know how it goes