Meal timing when using GHRP + GHRH peptides

The most annoying thing about using GHRPs like ipamorelin/GHRP2/GHRP6 and a GHRH like CJC1295 is having to time your meals and injections so that you get the biggest growth hormone release without worrying about an insulin spike or somatostatin interfering.

Almost every 'how to' guide on the internet says to wait 2 or even 3 hours after eating a meal depending on the fat content and to wait 30 minutes after your injection before you eat something, because fats and carbs blunt GH release.

But wait...

In an animal study on dairy cows given a GHRP (GHRP6) and GHRH, their GH levels were tested after being given the peptides on an empty stomach and also 1 hour after feeding. GHRP6 and GHRH induced secretion of GH was much lower 1 hour after feeding (22.5ng/ml and 20 ng/ml respectively) than 1 hour before feeding (53.5ng/ml and 64.5 ng/ml respectively).

However, a combination of GHRP6+GHRH together synergistically induced an equal and massive release of GH before and after feeding that was fivefold greater than GHRH-induced release of GH after feeding. It is likely that there is a change in receptor signaling after feeding that is overcome by stimulating GHRH and GHRP6 receptors together, while remaining refractory to either peptide alone.

The text in bold quoted from the study.


The abstract for this study is available on Pubmed.

Also, a doctor who is researching GHRP and GHRH peptides did a blood test to test his GH levels after injecting 100mcg GHRP2 + 100mcg CJC1295 w/o DAC on an empty stomach and tested again after injecting immediately after eating a high fat/carb/protein meal. The results:

GHRP2 100mcg +CJC1295 w/o DAC 100mcg on Empty stomach: 19.5ng/mL
GHRP2 100mcg +CJC1295 w/o DAC 100mcg after bigass meal: 18.9ng/mL

That's an insignificant 3% difference.

So it goes to show that if you are using BOTH a GHRP (ipamorelin/GHRP2/GHRP6) and a GHRH then this nonsense about having to wait 2-3 hours after eating before you can do your shot is outdated advice.

Nice. I actually found this on "Dat's" site as well. Nice to see the study as well with additional info. Good job, bud.

P.S. enjoyed your ipam article. nice and concise. +1

You don't even know how amazing it is to hear that haha... If I could give u 10 karma I would, that was my only downfall to the peptides, being timing in conjunction with meals, yet again great article bro

Yes this is great news hey. I have really been enjoying these peptides except for timing of injections. I will confirm this info with my own blood tests when I get more ipam/cjc but the research looks solid to me.

Well last night I had my pin with a meal, and I slept like a champ. Just like I used to when I had to watch meal times.. Only way to make sure like u say is with bloods

do al the how to guides say that the same for gh pins ? I am assuming yes right ?

so whats the best timing WRT meals and training on IGF-LR3 ?

Thanks MA ive been looking at using GHRP-6 for my appetite soon, so im glad i stumbled on this before starting!

Mr T wrote: Thanks MA ive been looking at using GHRP-6 for my appetite soon, so im glad i stumbled on this before starting!

This only applies if you are also using the GHRP6 with a GHRH like CJC1295 w/o DAC. Otherwise you must time your shots with your meals properly if you want any benefit besides an appetite. Although GHRP6 on its own won't do much as far as HGH benefits go.

@MA O Okay well im not too worried about the HGH benefits cos money is tight at the moment ill be using it primarily for my appetite, would you recommend the normal 3x 100 mcg or could i get away with 2 x 100mcg(ie 7am and 5pm) and still experience the appetite benefits?

Great post, Ive come across before.

MA what are your thoughts on CJC 1295 without DAC and Ipamorelin stack..??
3x 90mcg morn pwo and evening.
Do you feel timing of meals will be important??
Also should one be using alternate subq areas away from gut??

j1pvt wrote: Great post, Ive come across before.

MA what are your thoughts on CJC 1295 without DAC and Ipamorelin stack..??
3x 90mcg morn pwo and evening.
Do you feel timing of meals will be important??
Also should one be using alternate subq areas away from gut??

It's a great stack. I can definitely recommend it. I also did 3 times a day and noticed good fat loss and general toning up, improvement in skin tone and after 2 to 3 months my hair looked thicker. I don't think it did too much in the way of gains but I had a general better feeling of well being. I also sometimes switch to preworkout shots because of the awesome pump.