I am currently running MOTS c for the second time as part of a cycle.
My first cycle I had a really irritating histamine type reaction to the MOTS, especially at the belly pin sites. It created a big red weld, that would ich for days on end. Keeping in mind, I follow proper sterile protocol and it happend with different brands. I shifted to pinning in the ass and mixing BPC 157 into the same syringe, that made it a bit more bearable and finished a 10 week cycle.
For my second and current cycle I first ran a 4 week ss31 cycle, and also introduced NAD+ after researching (now here is a different beast). The NAD+ has been studied for its potential to modulate histamine reactions, and for me it's definatly working as I have not had a single histimane reaction from MOTSc since I started the new cycle. Also worth a mention I switched to IM pinning into the quads.
For me NAD+ will be my base going forward, and in combination with the MOTSc my energie levels are supercharged. Even my preworkout hits harder.
But yea, peoples reactions to these peptides differ.