Sculpt Gel : Burn Fat Where YOU decide!

i recon i am gonna stick all the people doing cutting diets on sculpt,clen and some form of AI/serm...that will be a top notch combination!

been reading up a bit on dan duchaines work,and in his dirty dieting newsletter he talks about how effective a YOHIMBINE HCL topical cream is for cutting lower body fat,espicially effective in women. Dan Duchaine is one of the original chemical and diet gurus of the years gone past....

Started on some yesterday,

Lab Rat for the clients will keep you guys posted;)

Peace

moose i also just put a competitor on it,he is already extremely lean but we need him shredded,i will post up pics of him later and then again on the day of the show to show how the product really works....

picking mine up today.just getting 1 bottle for now,gonna use it before morning cardio and before afternoon training

yo,, way to pricey..

I will stick to clen and Riverzine.. get both for the same price.

the only problem with using reverzine is that the area that you can spot reduce in is small,Sculpt can cover more surface area therefore be more effective,reverzine will be concentrated in 1 small area where as sculpt can be applied to a large area blocking more alpha cells and releasing fat.

I will buy some to try, but like Acid I was also coughing when I heard the price.... Especially for a months supply...

If you have any influence on it I would maybe bring it up as an issue raised, Sculpt Gel....

ultimate thug i have been in contact with the guys about the product, it contains 20mg of yohimbine HCL per 4 squirts,that about the same as using 1.5-2.0mls of reverzine per shot, now,a bottle is only 20mls and u are getting a bottle for only slightly cheaper than sculpt,then u have to buy insulin needles at about R26 for 10,so u can see that the price isnt that high

DJ wrote:

ultimate thug i have been in contact with the guys about the product, it contains 20mg of yohimbine HCL per 4 squirts,that about the same as using 1.5-2.0mls of reverzine per shot, now,a bottle is only 20mls and u are getting a bottle for only slightly cheaper than sculpt,then u have to buy insulin needles at about R26 for 10,so u can see that the price isnt that high

Okay fair but how much of that 1.5 - 2mls of Yohimbine actually reaches the blood stream and/or fat cells? Where as with the inj version I would thinks this figure is close to 100%.

vega5 wrote:

DJ wrote:

ultimate thug i have been in contact with the guys about the product, it contains 20mg of yohimbine HCL per 4 squirts,that about the same as using 1.5-2.0mls of reverzine per shot, now,a bottle is only 20mls and u are getting a bottle for only slightly cheaper than sculpt,then u have to buy insulin needles at about R26 for 10,so u can see that the price isnt that high

Okay fair but how much of that 1.5 - 2mls of Yohimbine actually reaches the blood stream and/or fat cells? Where as with the inj version I would thinks this figure is close to 100%.

Yeah, that's a good point!

@Dj thanks for explaining that my blonde little hairs wouldnt know how to think like that...

@Vega5 with the transport system that is used it means that 97% of the yohimbine HCL will reach the target area... sales are sky rocketing already thanks to the adverts in the ME and Fitness magazine!

i know DJ has refered a competitor to us who will be using sculpt for the last 3 weeks before his show on his abs and glutes,i have posted up pics on the sculpt gel facebook group,i will also post up pics of him on the day of the show,he is a 21year old little monster and all natural...he is a novice competing for his first year,he has a good chance of winning the Border classic open u21 under 75kg line up!

hopefully he will have shredded glutes by show day

admin wrote:

vega5 wrote:

DJ wrote:

ultimate thug i have been in contact with the guys about the product, it contains 20mg of yohimbine HCL per 4 squirts,that about the same as using 1.5-2.0mls of reverzine per shot, now,a bottle is only 20mls and u are getting a bottle for only slightly cheaper than sculpt,then u have to buy insulin needles at about R26 for 10,so u can see that the price isnt that high

Okay fair but how much of that 1.5 - 2mls of Yohimbine actually reaches the blood stream and/or fat cells? Where as with the inj version I would thinks this figure is close to 100%.

Yeah, that's a good point!

The biopharmaceutics of yohimbine (YO) and the pharmacokinetics of 10-hydroxy-yohimbine (10-OH-YO) and 11-hydroxy-yohimbine (11-OH-YO) were investigated in healthy subjects following i.v. (5 mg) and oral (8 mg) dosing. One subject was found as a slow hydroxylator of YO. The mean (+/-S.D.) oral absolute bioavailability of YO was 22.3+/-21. 5%. Total plasma clearance (CL) and renal clearance (CL(r)) of YO following i.v. dosing were 0.728+/-0.256 ml/min and 0.001+/-0.002 ml/min, respectively. Based on the steady-state volume of distribution (V(ss)), YO had a relatively low distribution (V(ss) = 32.2+/-12.1 l). The overall renal excretion of YO, 10-OH-YO and 11-OH-YO, expressed as percent of the dose of YO administered, were not different following i.v. and oral dosing, and were around 0.1, 0.2 and 14%, respectively. Following i.v. dosing of YO, the mean apparent terminal half-life of 11-OH-YO (347+/-63 min) was almost four times higher than that of YO (91.0+/-33.6 min) suggesting an elimination rate-limited kinetics for 11-OH-YO.

Pharmacokinetic profiles were determined in seven healthy young male subjects following single oral and intravenous doses of 10 mg of yohimbine hydrochloride. The drug was rapidly eliminated (t1/2 beta 0.58 h orally and t1/2 beta 0.68 h intravenously). Following intravenous administration the data fit a two-compartment pharmacokinetic model, with a very rapid distribution phase (t1/2a was approximately 6 min). Both the oral and the intravenous yohimbine clearance values were high but oral clearance values were much higher (mean 9.77 ml.min-1.kg-1 intravenous versus 55.9 ml.min-1.kg-1 oral). The oral bioavailability showed great variability, ranging from 7% to 87% (mean value was 33%). The incomplete oral bioavailability of yohimbine may reflect either incomplete absorption from the gastrointestinal tract or an hepatic first pass effect. Although yohimbine is rapidly absorbed when given orally, the bioavailability is quite variable and considerable individualization of dosing may be necessary when the drug is used orally for clinical indications.

Seems that even the injectable and oral have a low bioavailability, so the transdermal can't be better... Should even be less.

admin wrote:

admin wrote:

vega5 wrote:

DJ wrote:

ultimate thug i have been in contact with the guys about the product, it contains 20mg of yohimbine HCL per 4 squirts,that about the same as using 1.5-2.0mls of reverzine per shot, now,a bottle is only 20mls and u are getting a bottle for only slightly cheaper than sculpt,then u have to buy insulin needles at about R26 for 10,so u can see that the price isnt that high

Okay fair but how much of that 1.5 - 2mls of Yohimbine actually reaches the blood stream and/or fat cells? Where as with the inj version I would thinks this figure is close to 100%.

Yeah, that's a good point!

The biopharmaceutics of yohimbine (YO) and the pharmacokinetics of 10-hydroxy-yohimbine (10-OH-YO) and 11-hydroxy-yohimbine (11-OH-YO) were investigated in healthy subjects following i.v. (5 mg) and oral (8 mg) dosing. One subject was found as a slow hydroxylator of YO. The mean (+/-S.D.) oral absolute bioavailability of YO was 22.3+/-21. 5%. Total plasma clearance (CL) and renal clearance (CL(r)) of YO following i.v. dosing were 0.728+/-0.256 ml/min and 0.001+/-0.002 ml/min, respectively. Based on the steady-state volume of distribution (V(ss)), YO had a relatively low distribution (V(ss) = 32.2+/-12.1 l). The overall renal excretion of YO, 10-OH-YO and 11-OH-YO, expressed as percent of the dose of YO administered, were not different following i.v. and oral dosing, and were around 0.1, 0.2 and 14%, respectively. Following i.v. dosing of YO, the mean apparent terminal half-life of 11-OH-YO (347+/-63 min) was almost four times higher than that of YO (91.0+/-33.6 min) suggesting an elimination rate-limited kinetics for 11-OH-YO.

Pharmacokinetic profiles were determined in seven healthy young male subjects following single oral and intravenous doses of 10 mg of yohimbine hydrochloride. The drug was rapidly eliminated (t1/2 beta 0.58 h orally and t1/2 beta 0.68 h intravenously). Following intravenous administration the data fit a two-compartment pharmacokinetic model, with a very rapid distribution phase (t1/2a was approximately 6 min). Both the oral and the intravenous yohimbine clearance values were high but oral clearance values were much higher (mean 9.77 ml.min-1.kg-1 intravenous versus 55.9 ml.min-1.kg-1 oral). The oral bioavailability showed great variability, ranging from 7% to 87% (mean value was 33%). The incomplete oral bioavailability of yohimbine may reflect either incomplete absorption from the gastrointestinal tract or an hepatic first pass effect. Although yohimbine is rapidly absorbed when given orally, the bioavailability is quite variable and considerable individualization of dosing may be necessary when the drug is used orally for clinical indications.

Seems that even the injectable and oral have a low bioavailability, so the transdermal can't be better... Should even be less.

I was just about to say, 97% is a nice statement to make without scientific studies to back this statement up?

Don't get me wrong,I'll still try it, but it is expensive... Sales sky rocketing only proves humankinds constant search for the elusive wonder drug.

PMID: 8697059

The fat on women's thighs is more difficult to mobilize due to increased alpha-2 adrenergic receptor activity induced by estrogen. Lipolysis can be initiated through adipocyte receptor stimulation (beta adrenergic) or inhibition (adenosine or alpha-2 adrenergic) or by inhibition of phosphodiesterase. Since many women desire regional thigh fat loss, a series of clinical trials were initiated using one thigh as a double-blinded control. Trial #1: Five overweight women had injections of isoproterenol at intervals around the thigh three times a week for 4 weeks with diet and walking. Trial #2: Five overweight woman had ointment containing forskolin, yohimbine and aminophylline applied to the thigh five times a week for 4 weeks after hypertonic warm soaks with a diet and walking. Trial #3: Eighteen overweight women were divided into three groups of six and trial #2 was repeated with each agent alone vs. placebo using forskolin, yohimbine or aminophylline in separate ointments. Trial #4: Thirty overweight women had 10% aminophylline ointment applied to the thigh five times a week for 6 weeks with diet and walking. Chemistry panel, theophylline level and patch testing were performed. Trial #5: Twelve women had trial #4 repeated with 2% aminophylline cream without a diet or walking. Trial #6: Trial #5 was repeated with 0.5% aminophylline cream. All trials except yohimbine ointment gave significantly more girth loss from the treated thigh (p < 0.05 to p < 0.001). Chemistry panel showed no toxicity. Theophylline was undetectable and patch testing was negative. We conclude that topical fat reduction for women's thighs can be achieved without diet or exercise.

admin wrote:

PMID: 8697059

The fat on women's thighs is more difficult to mobilize due to increased alpha-2 adrenergic receptor activity induced by estrogen. Lipolysis can be initiated through adipocyte receptor stimulation (beta adrenergic) or inhibition (adenosine or alpha-2 adrenergic) or by inhibition of phosphodiesterase. Since many women desire regional thigh fat loss, a series of clinical trials were initiated using one thigh as a double-blinded control. Trial #1: Five overweight women had injections of isoproterenol at intervals around the thigh three times a week for 4 weeks with diet and walking. Trial #2: Five overweight woman had ointment containing forskolin, yohimbine and aminophylline applied to the thigh five times a week for 4 weeks after hypertonic warm soaks with a diet and walking. Trial #3: Eighteen overweight women were divided into three groups of six and trial #2 was repeated with each agent alone vs. placebo using forskolin, yohimbine or aminophylline in separate ointments. Trial #4: Thirty overweight women had 10% aminophylline ointment applied to the thigh five times a week for 6 weeks with diet and walking. Chemistry panel, theophylline level and patch testing were performed. Trial #5: Twelve women had trial #4 repeated with 2% aminophylline cream without a diet or walking. Trial #6: Trial #5 was repeated with 0.5% aminophylline cream. All trials except yohimbine ointment gave significantly more girth loss from the treated thigh (p < 0.05 to p < 0.001). Chemistry panel showed no toxicity. Theophylline was undetectable and patch testing was negative. We conclude that topical fat reduction for women's thighs can be achieved without diet or exercise.

maybe the trial was not effective due to the transport system,The Sculpt Transport system might be a DSMO solution which would be more effective than any other ointment used to transport yohimbine through the skin.i will clarify later....

Sculpt Gel wrote:

maybe the trial was not effective due to the transport system,The Sculpt Transport system might be a DSMO solution which would be more effective than any other ointment used to transport yohimbine through the skin.i will clarify later.

DMSO

Beesting wrote:

Sculpt Gel wrote:

maybe the trial was not effective due to the transport system,The Sculpt Transport system might be a DSMO solution which would be more effective than any other ointment used to transport yohimbine through the skin.i will clarify later.

DMSO

I read an interisting article now about DMSO, tests are being done on GABBA with DMSO, still oral though, and there seems to be proof that it can significantly improves the passing of the blood brain barrier, which is the problem with the standard variety.

Sculpt Gel, I'm not being an ass, I hope this stuff works and will tell all if it does, we need to give you shit to find out as much as we can , as we've been ripped before.

UltimateThug,Dont worry,i know exactly how you feel,i am just marketing the product for the manufactures and when they approached me i was very skeptical,i have used reverzine before and well it worked very well,the only problem is the twice daily injections,and i hate needles,i just cant stand them... so when they told me its exactly the same thing as reverzine in an effecitve transport system/gel that passes through the skin instead of injecting it thats when my view point changed about the product,as a woman i have tried hundreds of products that claim to burn fat and reduce cellulite etc and that was all marketing crap.

i told the client i would not be willing to market a product that i am not 100% certain works as i do have ethics to uphold,so they said that is fine,they left a bottle with me to use for myself personally and said they would be in contact in 4 weeks. well let me say this,i am not very active at all,i am a desk jockey,dont train and live a diet of when i am hungry i eat,and i eat what i feel like, generally having 2 glasses of coke a day. i am a naturally slim and trim girl but have got what i think is a bit of a big bum and hips(my boyfriend doesn't agree,bless his heart) so i used the product for the 4 weeks, and after taking measurements before i started,and after i started i noticed a 5cm drop in the measurement of my hips and butt area...and i didnt even change my diet... i am the biggest sceptic but when the results like that come up well then i am changed into a believer.

i know that there are a few competitive bodybuilders currently using sculpt for their contest prep : Chris Fitspatrick(SSN sponsored Athlete) Bruce Namhing(SSN Sponsored Athlete) John Lucas(winner of the nabba tall man class 2009) Jacques Van Der Linde(SA Fame Pro) and a few other athletes...

i have an ethics code that i need to uphold in my businesses and well i wouldn't market a product that i wasn't certain works!

i have been in contact with my manufacturers,and we do not use a DMSO solution,i will list the ingredients of the transport system as soon as they have been sent through to me!

Give me free samples and I will say it awesome... Till then I am clen and Riverzine / Reva - ject fan

hahahahahaha always clowning around hey

guys i have just bought a bottle for my lady,i will slap some tan on her this weekend and take a photo of the areas she will be applying,she will be applying to the buttocks and abdomen twice a day,she works a full time job and doesnt diet or exercise so it will be a good way to judge!i will then take photos two weeks post and then 4 weeks post starting sculpt and will report back the results!!! (yes you will get to see my chicks ass )

DJ wrote:

hahahahahaha always clowning around hey

guys i have just bought a bottle for my lady,i will slap some tan on her this weekend and take a photo of the areas she will be applying,she will be applying to the buttocks and abdomen twice a day,she works a full time job and doesnt diet or exercise so it will be a good way to judge!i will then take photos two weeks post and then 4 weeks post starting sculpt and will report back the results!!! (yes you will get to see my chicks ass )

Awesome DJ,please could you ask her if we could use the photos on our website and ask her for a testimonial?

did my editing privilages get taken away admin?i was gonna edit the posts...

DJ wrote:

did my editing privilages get taken away admin?i was gonna edit the posts...

Updating forum now, so all moderators are back to normal users... only their status show up as moderator.

aaaaaah ok...was wondering...cool