GW-501516 from Liquid-Pharma

On Cycle - TestE/Deca/NPP/Masteron - Using 20mg/day of the stuff. Lost 2Kg in 1 week.

But... Power down and running out of puff very quickly.

Pumps are crazy - too much actually. Cant get through my old routine.
Gonna give this a skip for now.

Got 7 bottles of the stuff, waiting till i start hitting the carbs... Im so over 130 bpm cardio with this current diet of mine. Im use to pushing my self to the limits with cardio.

So how long did it take for you guys to notice the increase in endurance?

That's the first thing you notice in the first couple of days

ABC01 wrote: So how long did it take for you guys to notice the increase in endurance?

:S Thats whats missing and my complaint - Power down 30-40% And no freakin air!
Dropping everything to basics - have to find te culprit.

Anyone have an idea of the maximum recommended period to take GW? Is this something you can take ED for months on end?

jackrabbit1 wrote:

ABC01 wrote: So how long did it take for you guys to notice the increase in endurance?

:S Thats whats missing and my complaint - Power down 30-40% And no freakin air!
Dropping everything to basics - have to find te culprit.

This is a bit worrying Rabbit! Endurance would be the only reason i would want to take it

Found a nice article on steroidology.com posted last week.


Don't want to paste the entire article but some of the information mentioned in it correlates to my experience with GW.

"Aside from its well-known fat-loss enhancing qualities, GW has been shown to have many protective qualities as well. GW has been shown in research to have muscular protective and enhancing effects and this seems to be related to a decrease in muscle inflammation and damage."

Source : www.steroidology.com/forum/burning-fat/6...le-find-out-how.html

INB4 wrote: Source : www.steroidology.com/forum/burning-fat/6...le-find-out-how.html

Extract
There are small incidences documented in a very small number of studies with PRAR Modulators with one indirect effect that may be prudent to address. Apparently there is a small increase in the likelihood of research subjects developing stomach polyps. While this is worth being aware of, the good news is in those very same studies it is documented that administration of a COX-2 inhibitor virtually eliminates this increased possibility.


Good thing I'm already on Tribulus. Adds some concern to the use of GW though. Not a chance I'm taking a COX-2 inhibitor to enable taking GW...

The research subjects were rodents. Have you found any info where this is linked to human subjects as well?

Hi

Replying on an old post, but I have some questions, and I see that your lab rate used GW501516. I got my first batch last week. Marathon runner and need some advise if possible from the experience and dosis used by your wife. I really am desperate for advise. Running Ultra this coming weekend.

esterhch wrote: Hi

Replying on an old post, but I have some questions, and I see that your lab rate used GW501516. I got my first batch last week. Marathon runner and need some advise if possible from the experience and dosis used by your wife. I really am desperate for advise. Running Ultra this coming weekend.

10mg daily.

will this dose last through a 50km race, or can you consider taking another 10mg at half way?

esterhch wrote: will this dose last through a 50km race, or can you consider taking another 10mg at half way?

Eish no, the GW is not used as "fuel" to give you energy for 50km. It's there to increase endurance by affecting energy release.

Take 10mg finish en klaar.

Ok thanks. Was hoping for some improvement on my half marathon yesterday, but did not notice a difference, I suppose time is the key as I have only started 10mg a day from last week..
Thanks for the response.

GW501516 has a very long half life so exact timing is not very important.

Great so this week after being on GW for a few months I suddenly see an explosion of articles stating that GSK has stopped the research, and that GW promotes cancer,
This has not yet been proven on humans as the study lengths differed between humans and the "marathon mice"
Just to be on the safe side I think for now until more info comes out I will be giving this a skip.

I will add links as I get them


theconversation.com/anti-doping-agency-w...s-of-endurobol-12997
www.newscientist.com/article/mg21729103....ack-market-drug.html


LoL "endurobol" is the street name now, much easier to say than gw501516

There will always be a big cancer fuzz over performance drugs, but what about Alchohol, Nikotine and a few others ?

Hey INB4

What were your results as far as fat loss is concerned..?

Boys boys boys, you are Playing with a carcinogenic... Theres a reason glaxosmithkline stopped further research into it...

GeneralJ wrote: Boys boys boys, you are Playing with a carcinogenic... Theres a reason glaxosmithkline stopped further research into it...

Interested to see where you go from this first post.

GeneralJ wrote: Boys boys boys, you are Playing with a carcinogenic... Theres a reason glaxosmithkline stopped further research into it...

What's the official reason from glaxosmithkline for discontinuing GW?

admin wrote:

GeneralJ wrote: Boys boys boys, you are Playing with a carcinogenic... Theres a reason glaxosmithkline stopped further research into it...

What's the official reason from glaxosmithkline for discontinuing GW?

Hi Admin. I found this on wiki:

GW501516 was initially discovered during a research collaboration between GSK and Ligand Pharmaceuticals that began in 1992.[9] R & D Focus Drug News reported that GSK began phase I trials of the compound for the treatment of hyperlipidemia in 2000[10] followed by phase I/II in 2002.[11] The discovery of the compound was published in a 2001 issue of PNAS.[12] Oliver et al. reported that they used "combinatorial chemistry and structure-based drug design" to develop it.[13] One of the authors was the son of Leo Sternbach who discovered benzodiazepines in the 1960s.[14] In 2003, Ligand Pharmaceuticals earned a $1 million payment as a result of GSK continuing phase I development.[15]
GW501516 had completed two phase II clinical studies but GSK abandoned further development of the drug in 2007 for reasons which where not disclosed as of 2008

en.wikipedia.org/wiki/GW501516

but I posted THIS and also found a warning on their site:

News Release - May 24, 2013
Serious risks associated with use of the unauthorized product GW501516



GlaxoSmithKline Inc. (GSK), in consultation with Health Canada, would like to inform you that a compound referred to as GW501516 is being made available for sale to Canadians via the internet. This compound may be abused by some athletes for performance enhancement. It is not known if the product available via the internet and sold as GW501516 is actually GW501516 or another compound.

GW501516 is not approved for use in humans and has never been manufactured nor distributed by GSK. GW501516 was being developed to raise HDL or "good" cholesterol in patients with abnormal cholesterol levels in their blood. In 2006, GSK stopped clinical development of GW501516 when toxicities, including a variety of cancers, were discovered following routine, long term animal studies.

An unauthorized product, known as GW501516, is being made available on the internet.
All clinical development of GW501516 was stopped when toxicities, including various cancers, were discovered following routine, long term animal studies. The long-term effects of GW501516 in humans are unknown.
Canadians are advised not to use this product under any circumstances and should consult with a health care professional if they have concerns about their health related to its use.
GW501516 is not approved for use in humans. GSK does not manufacture or authorize its sale.

www.gsk.ca/english/html/media-centre/2013-05-23.html

As far as i know the rats developed cancer very aggresively in experimental phase. This is all i know so far , but other forums the hype of GW was also huge but after a while the the guys stopped using because of the claims of it being such a powerful carcinogen. I guess that was GMK main reason for dropping further research.

In 2013 (New Scientist) reported that "tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb."[4] In 2013 WADA took the rare step of warning potential users of the compound of the possible health risks. They stated "clinical approval has not, and will not be given for this substance".[2][24]

This is what wikipedia's got but ill go ask my oncology proff this week what his thoughts are and try and give a better answer.

To MA, do u think this is a safe drug to use at the10mg dosage?