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Stanabolic wrote: I think of most of those logs are over at promuscle? One guy has been on it for 3 years and won't go off because he loves it so much and I think he also said he had cholesterol problems and GW sorted that out quite well. From the sounds of things you have to stay on pretty consistently for it to improve cholesterol.
OBJECTIVE:
Peroxisome proliferator-activated receptor-δ-induced upregulation in skeletal muscle fatty acid oxidation would predict the modulation of lipid/lipoproteins.
METHODS AND RESULTS:
GW501516 (2.5, 5.0, or 10.0 mg) or placebo was given for 12 weeks to patients (n=268) with high-density lipoprotein (HDL) cholesterol <1.16 mmol/L. Fasting lipids/apolipoproteins (apos), insulin, glucose, and free fatty acid were measured; changes from baseline were calculated and assessed. A second smaller exploratory study (n=37) in a similar population was conducted using a sequence of 5 and 10 mg dosing for the assessment of lipoprotein particle concentration. GW501516 demonstrated HDL cholesterol increases up to 16.9% (10 mg) and apoA-I increases up to 6.6%. Reductions were observed in low-density lipoprotein (LDL) cholesterol (-7.3%), triglycerides (-16.9%), apoB (-14.9%), and free fatty acids (-19.4%). The exploratory study showed significant reductions in the concentration of very LDL (-19%), intermediate-density lipoprotein (-52%), and LDL (-14%, predominantly a reduction in small particles), whereas the number of HDL particles increased (+10%; predominantly medium and large HDL).
CONCLUSIONS:
GW501516 produced significant changes in HDL cholesterol, LDL cholesterol, apoA1, and apoB. Fewer very LDL and larger LDL support a transition toward less atherogenic lipoprotein profiles. These data are consistent with peroxisome proliferator-activated receptor-δ being a potentially important target for providing cardiovascular protection in metabolic syndrome-like patients.
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gab wrote: yip that is a huge bonus in my books. i wonder how much it will help when your on cycle? cholesterol meds is not so good when on cycle as it makes getting a stiffy more difficult sometimes.
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MCJ wrote: I see that its recommended to use this with AICAR (commonly under the name Acadesine). Now in simple terms what is this Acadesine and what does it do? And secondly would this also be available? Could a person use the GW without running the Acadesine as well?
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Muscleaddict wrote:
MCJ wrote: I see that its recommended to use this with AICAR (commonly under the name Acadesine). Now in simple terms what is this Acadesine and what does it do? And secondly would this also be available? Could a person use the GW without running the Acadesine as well?
Check here:
www.emaxhealth.com/69/23617.html
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Eidolon wrote: Did you exercise during this time, DJ?
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big jay wrote: Admin is the realse date still going to happen as planned? So we should be able to get it next week sometime? Thanks
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DJ wrote: Yes, 5 training sessions a week and 3 kettle bell sessions a week
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DJ wrote: Ok well I was an impatient monkey waiting for LP to come out with this product so I ordered some from over seas,well, I used 5mg a day for 4days then went up to 10mg a day for about a week now, now some people say there is a build up period for this stuff,but I haven't felt/seen any benefits other than being slightly warmer,other than that,no visable weight or fat loss...I do how ever after 2hours after taking the stuff my guts do drop. I will be taking 20mg daily when the LP version does become released....
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